%0 Journal Article
%A Malchers, Florian
%A Nogova, Lucia
%A van Attekum, Martijn Ha
%A Maas, Lukas
%A Brägelmann, Johannes
%A Bartenhagen, Christoph
%A Girard, Luc
%A Bosco, Graziella
%A Dahmen, Ilona
%A Michels, Sebastian
%A Weeden, Clare E
%A Scheel, Andreas H
%A Meder, Lydia
%A Golfmann, Kristina
%A Schuldt, Philipp
%A Siemanowski, Janna
%A Rehker, Jan
%A Merkelbach-Bruse, Sabine
%A Menon, Roopika
%A Gautschi, Oliver
%A Heuckmann, Johannes M
%A Brambilla, Elisabeth
%A Asselin-Labat, Marie-Liesse
%A Persigehl, Thorsten
%A Minna, John D
%A Walczak, Henning
%A Ullrich, Roland T
%A Fischer, Matthias
%A Reinhardt, Hans Christian
%A Wolf, Jürgen
%A Büttner, Reinhard
%A Peifer, Martin
%A George, Julie
%A Thomas, Roman K
%T Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer.
%J The journal of clinical investigation
%V 133
%N 21
%@ 0021-9738
%C Ann Arbor, Mich.
%I ASCJ
%M DKFZ-2023-02256
%P e170217
%D 2023
%X The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11
%K Humans
%K Lung Neoplasms: drug therapy
%K Lung Neoplasms: genetics
%K Lung Neoplasms: pathology
%K Gene Amplification
%K Carcinoma, Non-Small-Cell Lung: drug therapy
%K Carcinoma, Non-Small-Cell Lung: genetics
%K Carcinoma, Squamous Cell: genetics
%K Carcinoma, Squamous Cell: pathology
%K Receptor, Fibroblast Growth Factor, Type 1: genetics
%K Receptor, Fibroblast Growth Factor, Type 1: metabolism
%K Protein Kinase Inhibitors: pharmacology
%K Epithelial Cells: metabolism
%K Drug therapy (Other)
%K Genetics (Other)
%K Lung cancer (Other)
%K Oncology (Other)
%K Receptor, Fibroblast Growth Factor, Type 1 (NLM Chemicals)
%K Protein Kinase Inhibitors (NLM Chemicals)
%K FGFR1 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37606995
%2 pmc:PMC10617767
%R 10.1172/JCI170217
%U https://inrepo02.dkfz.de/record/285132