TY  - JOUR
AU  - Malchers, Florian
AU  - Nogova, Lucia
AU  - van Attekum, Martijn Ha
AU  - Maas, Lukas
AU  - Brägelmann, Johannes
AU  - Bartenhagen, Christoph
AU  - Girard, Luc
AU  - Bosco, Graziella
AU  - Dahmen, Ilona
AU  - Michels, Sebastian
AU  - Weeden, Clare E
AU  - Scheel, Andreas H
AU  - Meder, Lydia
AU  - Golfmann, Kristina
AU  - Schuldt, Philipp
AU  - Siemanowski, Janna
AU  - Rehker, Jan
AU  - Merkelbach-Bruse, Sabine
AU  - Menon, Roopika
AU  - Gautschi, Oliver
AU  - Heuckmann, Johannes M
AU  - Brambilla, Elisabeth
AU  - Asselin-Labat, Marie-Liesse
AU  - Persigehl, Thorsten
AU  - Minna, John D
AU  - Walczak, Henning
AU  - Ullrich, Roland T
AU  - Fischer, Matthias
AU  - Reinhardt, Hans Christian
AU  - Wolf, Jürgen
AU  - Büttner, Reinhard
AU  - Peifer, Martin
AU  - George, Julie
AU  - Thomas, Roman K
TI  - Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer.
JO  - The journal of clinical investigation
VL  - 133
IS  - 21
SN  - 0021-9738
CY  - Ann Arbor, Mich.
PB  - ASCJ
M1  - DKFZ-2023-02256
SP  - e170217
PY  - 2023
AB  - The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11
KW  - Humans
KW  - Lung Neoplasms: drug therapy
KW  - Lung Neoplasms: genetics
KW  - Lung Neoplasms: pathology
KW  - Gene Amplification
KW  - Carcinoma, Non-Small-Cell Lung: drug therapy
KW  - Carcinoma, Non-Small-Cell Lung: genetics
KW  - Carcinoma, Squamous Cell: genetics
KW  - Carcinoma, Squamous Cell: pathology
KW  - Receptor, Fibroblast Growth Factor, Type 1: genetics
KW  - Receptor, Fibroblast Growth Factor, Type 1: metabolism
KW  - Protein Kinase Inhibitors: pharmacology
KW  - Epithelial Cells: metabolism
KW  - Drug therapy (Other)
KW  - Genetics (Other)
KW  - Lung cancer (Other)
KW  - Oncology (Other)
KW  - Receptor, Fibroblast Growth Factor, Type 1 (NLM Chemicals)
KW  - Protein Kinase Inhibitors (NLM Chemicals)
KW  - FGFR1 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37606995
C2  - pmc:PMC10617767
DO  - DOI:10.1172/JCI170217
UR  - https://inrepo02.dkfz.de/record/285132
ER  -