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000285362 1001_ $$aPerna, Laura$$b0
000285362 245__ $$aSubjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study.
000285362 260__ $$aLondon$$bBioMed Central$$c2023
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000285362 520__ $$aSubjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer's disease in memory clinic settings. The potential of combining SCC with genetic information and blood biomarkers of neurodegenerative diseases for risk assessment of dementia and depression in the absence of dementia among community-dwelling older adults has so far not been explored.Data were based on a population-based cohort of 6357 participants with a 17-year follow-up (ESTHER study) and a clinic-based cohort of 422 patients. Participants of both cohorts were grouped according to the diagnosis of dementia (yes/no) and the diagnosis of depression in the absence of dementia (yes/no). Participants without dementia included both cognitively unimpaired participants and cognitively impaired participants. Genetic information (APOE ε4 genotype) and blood-based biomarkers of neurodegenerative diseases (glial fibrillary acidic protein; GFAP, neurofilament light chain; NfL, phosphorylated tau181; p-tau181) were available in the ESTHER study and were determined with Simoa Technology in a nested case-control design. Logistic regression models adjusted for relevant confounders were run for the outcomes of all-cause dementia and depression in the absence of dementia.The results showed that persistent SCC were associated both with increased risk of all-cause dementia and of depression without dementia, independently of the diagnostic setting. However, the results for the ESTHER study also showed that the combination of subjective complaints with APOE ε4 and with increased GFAP concentrations in the blood yielded a substantially increased risk of all-cause dementia (OR 5.35; 95%CI 3.25-8.81, p-value < 0.0001 and OR 7.52; 95%CI 2.79-20.29, p-value < 0.0001, respectively) but not of depression. Associations of NfL and p-tau181 with risk of all-cause dementia and depression were not statistically significant, either alone or in combination with SCC, but increased concentrations of p-tau181 seemed to be associated with an increased risk for depression.In community and clinical settings, SCC predict both dementia and depression in the absence of dementia. The addition of GFAP could differentiate between the risk of all-cause dementia and the risk of depression among individuals without dementia.
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000285362 650_7 $$2Other$$aAPOE ε4
000285362 650_7 $$2Other$$aDementia
000285362 650_7 $$2Other$$aDepression
000285362 650_7 $$2Other$$aGlial fibrillary acidic protein
000285362 650_7 $$2Other$$aOlder people
000285362 650_7 $$2Other$$aSubjective cognitive decline
000285362 650_7 $$2NLM Chemicals$$aApolipoprotein E4
000285362 650_7 $$2NLM Chemicals$$aBiomarkers
000285362 650_7 $$2NLM Chemicals$$atau Proteins
000285362 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000285362 650_2 $$2MeSH$$aHumans
000285362 650_2 $$2MeSH$$aAged
000285362 650_2 $$2MeSH$$aLongitudinal Studies
000285362 650_2 $$2MeSH$$aNeurodegenerative Diseases: diagnosis
000285362 650_2 $$2MeSH$$aApolipoprotein E4: genetics
000285362 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000285362 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000285362 650_2 $$2MeSH$$aCohort Studies
000285362 650_2 $$2MeSH$$aCognition
000285362 650_2 $$2MeSH$$aBiomarkers
000285362 650_2 $$2MeSH$$atau Proteins: metabolism
000285362 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000285362 7001_ $$0P:(DE-He78)104fae0755c89365b7ae32238b3f1f52$$aStocker, Hannah$$b1$$udkfz
000285362 7001_ $$aBurow, Lena$$b2
000285362 7001_ $$aBeyer, Léon$$b3
000285362 7001_ $$0P:(DE-He78)b09508a4c4afe85c57dd131eefa689ea$$aTrares, Kira$$b4$$udkfz
000285362 7001_ $$aKurz, Carolin$$b5
000285362 7001_ $$aGürsel, Selim$$b6
000285362 7001_ $$0P:(DE-He78)53e1a2846c69064e27790dbf349ccaec$$aHolleczek, Bernd$$b7$$udkfz
000285362 7001_ $$aTatò, Maia$$b8
000285362 7001_ $$aBeyreuther, Konrad$$b9
000285362 7001_ $$aMons, Ute$$b10
000285362 7001_ $$aGerwert, Klaus$$b11
000285362 7001_ $$aPerneczky, Robert$$b12
000285362 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b13$$udkfz
000285362 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b14$$eLast author$$udkfz
000285362 773__ $$0PERI:(DE-600)2506521-X$$a10.1186/s13195-023-01341-3$$gVol. 15, no. 1, p. 198$$n1$$p198$$tAlzheimer's research & therapy$$v15$$x1758-9193$$y2023
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