000285364 001__ 285364
000285364 005__ 20240229155108.0
000285364 0247_ $$2doi$$a10.1007/s11356-023-30741-z
000285364 0247_ $$2pmid$$apmid:37950781
000285364 0247_ $$2ISSN$$a0944-1344
000285364 0247_ $$2ISSN$$a1614-7499
000285364 0247_ $$2altmetric$$aaltmetric:156417029
000285364 037__ $$aDKFZ-2023-02333
000285364 041__ $$aEnglish
000285364 082__ $$a690
000285364 1001_ $$0P:(DE-He78)7089188e1b7bdb788ba48ba96f21df07$$aXie, Ruijie$$b0$$eFirst author$$udkfz
000285364 245__ $$aAssociations of ethylene oxide exposure and 'Life's Essential 8'.
000285364 260__ $$aHeidelberg$$bSpringer$$c2023
000285364 3367_ $$2DRIVER$$aarticle
000285364 3367_ $$2DataCite$$aOutput Types/Journal article
000285364 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1702041548_10453
000285364 3367_ $$2BibTeX$$aARTICLE
000285364 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000285364 3367_ $$00$$2EndNote$$aJournal Article
000285364 500__ $$a#EA:C070# / 2023 Dec;30(57):121150-121160
000285364 520__ $$aEthylene oxide (EtO) is a widely used industrial chemical with recognized health risks. While its carcinogenic properties have been extensively studied, emerging evidence suggests potential associations with cardiovascular diseases. Using the recently introduced Life's Essential 8 (LE8) score as a comprehensive cardiovascular health (CVH) measure, this study aimed to elucidate the relationship between EtO exposure and CVH. Data from the National Health and Nutrition Examination Survey (NHANES) encompassing 3748 adults was analyzed. CVH was assessed using the LE8 score, which incorporates diet, physical activity, tobacco/nicotine exposure, sleep duration, BMI, non-HDL cholesterol, blood glucose, and blood pressure. The association between EtO exposure, gauged by Hemoglobin adduct (HbEtO) levels, and CVH was examined using linear regression and Cox regression models. An inverse relationship between EtO exposure and the overall CVH score was identified. Specifically, for every 1-unit increase in ln-transformed HbEtO, a 3.69-point decrease in the total CVH score was observed. An inverted J-shaped association between ln-transformed HbEtO and CVH score emerged, with an inflection point at 3.15 pmol/g Hb. Elevated EtO exposure was not significantly linked to all-cause mortality but was robustly associated with increased cardiovascular mortality. Elevated EtO exposure is negatively associated with CVH, as outlined by the LE8 metrics. Beyond a certain threshold, this association underscores the cardiovascular risks of EtO exposure and highlights the importance of further research to determine underlying mechanisms and recommend preventive strategies.
000285364 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000285364 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000285364 650_7 $$2Other$$aCardiovascular health
000285364 650_7 $$2Other$$aCardiovascular mortality
000285364 650_7 $$2Other$$aEthylene oxide
000285364 650_7 $$2Other$$aLife’s Essential 8
000285364 7001_ $$aLiu, Linjian$$b1
000285364 7001_ $$aLiu, Changxiong$$b2
000285364 7001_ $$aXie, Songlin$$b3
000285364 7001_ $$aHuang, Xiongjie$$b4
000285364 7001_ $$aZhang, Ya$$b5
000285364 773__ $$0PERI:(DE-600)2014192-0$$a10.1007/s11356-023-30741-z$$n57$$p121150-121160$$tEnvironmental science and pollution research$$v30$$x0944-1344$$y2023
000285364 909CO $$ooai:inrepo02.dkfz.de:285364$$pVDB
000285364 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7089188e1b7bdb788ba48ba96f21df07$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000285364 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000285364 9141_ $$y2023
000285364 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2023-10-22$$wger
000285364 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2023-10-22$$wger
000285364 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bENVIRON SCI POLLUT R : 2022$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-22
000285364 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bENVIRON SCI POLLUT R : 2022$$d2023-10-22
000285364 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000285364 9200_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000285364 980__ $$ajournal
000285364 980__ $$aVDB
000285364 980__ $$aI:(DE-He78)C070-20160331
000285364 980__ $$aUNRESTRICTED