TY - JOUR AU - Moen, Christian A AU - Falkenthal, Thea E AU - Thorkelsen, Tor K AU - Hopland, Andreas AU - Rio, Oline E AU - Honoré, Alfred AU - Juliebø-Jones, Patrick AU - Dongre, Harsh N AU - Costea, Daniela E AU - Bostad, Leif AU - Brennan, Paul AU - Johansson, Mattias AU - Ferreiro-Iglesias, Aida AU - Brenner, Nicole AU - Waterboer, Tim AU - Nygård, Mari AU - Beisland, Christian TI - Penile Cancers Attributed to Human Papillomavirus Are Associated with Improved Survival for Node-positive Patients. Findings from a Norwegian Cohort Study Spanning 50 Years. JO - European urology oncology VL - 7 IS - 4 SN - 2588-9311 CY - Amsterdam PB - Elsevier M1 - DKFZ-2023-02340 SP - 778-785 PY - 2024 N1 - 2024 Aug;7(4):778-785 AB - Human papillomavirus (HPV) infection is a risk factor for the development of penile squamous cell carcinoma (PSCC). It remains inconclusive whether HPV-related PSCC has a different prognosis from non-HPV-related PSCC.To investigate the relationship between HPV status and survival as well as temporal changes in the proportion of HPV-related PSCC.A retrospective cohort of 277 patients treated in Norway between 1973 and 2022 was investigated for HPV DNA in tumor tissue. Clinicopathological variables and disease course were registered.Kaplan-Meier curves and Cox regression were used to investigate the determinants of cancer-specific survival (CSS). The chi-square test for trend in proportions enabled investigation of temporal changes in the HPV-related proportion of PSCC patients treated in Western Norway (n = 211).HPV DNA was detected in tumor tissue from 131 (47 KW - Cancer-specific survival (Other) KW - Human papillomavirus (Other) KW - Net survival (Other) KW - Penile cancer (Other) KW - Penile squamous cell carcinoma (Other) LB - PUB:(DE-HGF)16 C6 - pmid:37949729 DO - DOI:10.1016/j.euo.2023.10.013 UR - https://inrepo02.dkfz.de/record/285371 ER -