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@ARTICLE{Moen:285371,
      author       = {C. A. Moen and T. E. Falkenthal and T. K. Thorkelsen and A.
                      Hopland and O. E. Rio and A. Honoré and P. Juliebø-Jones
                      and H. N. Dongre and D. E. Costea and L. Bostad and P.
                      Brennan and M. Johansson and A. Ferreiro-Iglesias and N.
                      Brenner$^*$ and T. Waterboer$^*$ and M. Nygård and C.
                      Beisland},
      title        = {{P}enile {C}ancers {A}ttributed to {H}uman {P}apillomavirus
                      {A}re {A}ssociated with {I}mproved {S}urvival for
                      {N}ode-positive {P}atients. {F}indings from a {N}orwegian
                      {C}ohort {S}tudy {S}panning 50 {Y}ears.},
      journal      = {European urology oncology},
      volume       = {7},
      number       = {4},
      issn         = {2588-9311},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-02340},
      pages        = {778-785},
      year         = {2024},
      note         = {2024 Aug;7(4):778-785},
      abstract     = {Human papillomavirus (HPV) infection is a risk factor for
                      the development of penile squamous cell carcinoma (PSCC). It
                      remains inconclusive whether HPV-related PSCC has a
                      different prognosis from non-HPV-related PSCC.To investigate
                      the relationship between HPV status and survival as well as
                      temporal changes in the proportion of HPV-related PSCC.A
                      retrospective cohort of 277 patients treated in Norway
                      between 1973 and 2022 was investigated for HPV DNA in tumor
                      tissue. Clinicopathological variables and disease course
                      were registered.Kaplan-Meier curves and Cox regression were
                      used to investigate the determinants of cancer-specific
                      survival (CSS). The chi-square test for trend in proportions
                      enabled investigation of temporal changes in the HPV-related
                      proportion of PSCC patients treated in Western Norway (n =
                      211).HPV DNA was detected in tumor tissue from 131 $(47\%)$
                      patients. Stratified by HPV status, 5-yr CSS did not differ
                      between groups (p = 0.37). When investigating only
                      node-positive patients, however, presence of HPV DNA was an
                      independent predictor of better survival in multivariable
                      Cox regression after adjustment for age, nodal stage, and
                      adjuvant therapy (hazard ratio 0.54, $95\%$ confidence
                      interval: [0.30-0.99], p = 0.04). In cases from Western
                      Norway, an increasing proportion of HPV-related cases over
                      time was found (p = 0.01). The main limitation is the
                      retrospective study design.HPV DNA in tumor tissue was
                      associated with significantly better CSS for node-positive
                      patients. The proportion of HPV DNA-positive PSCC has
                      increased significantly in Western Norway over the past 50
                      yr.We investigated the impact of human papillomavirus (HPV)
                      on the survival of penile cancer patients treated over a
                      50-yr period in Norway. We found that for patients with
                      lymph node metastasis, survival was better for HPV-related
                      cases. We also found that the proportion of cases due to HPV
                      has increased in Western Norway.},
      keywords     = {Cancer-specific survival (Other) / Human papillomavirus
                      (Other) / Net survival (Other) / Penile cancer (Other) /
                      Penile squamous cell carcinoma (Other)},
      cin          = {F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37949729},
      doi          = {10.1016/j.euo.2023.10.013},
      url          = {https://inrepo02.dkfz.de/record/285371},
}