TY  - JOUR
AU  - Decker, Nina Sophia
AU  - Johnson, Theron
AU  - Vey, Johannes A
AU  - Le Cornet, Charlotte
AU  - Behrens, Sabine
AU  - Obi, Nadia
AU  - Kaaks, Rudolf
AU  - Chang-Claude, Jenny
AU  - Turzanski-Fortner, Renée
TI  - Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort.
JO  - BMC medicine
VL  - 21
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2023-02355
SP  - 438
PY  - 2023
N1  - #EA:C020#LA:C020#
AB  - Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated with breast cancer-specific and non-breast cancer-related deaths are of importance. Emerging evidence suggests a role of oxysterols, derivates of cholesterol, in multiple chronic diseases including breast cancer and coronary artery diseases. However, associations between oxysterols and survival have been minimally studied in women diagnosed with breast cancer. In this large breast cancer patient cohort, we evaluated associations between a panel of circulating oxysterols and mortality and recurrence outcomes.Concentrations of 13 circulating oxysterols representing different pathways of cholesterol metabolism were quantified using liquid-chromatography mass-spectrometry. Associations between baseline levels of oxysterols and cause-specific mortality outcomes and recurrence following a breast cancer diagnosis were assessed in 2282 women from the MARIE study over a median follow-up time of 11 years. We calculated hazard ratios (HR) and 95
KW  - Breast cancer (Other)
KW  - Cancer death (Other)
KW  - Cardiovascular death (Other)
KW  - Cholesterol metabolism (Other)
KW  - Cohort study (Other)
KW  - Molecular epidemiology (Other)
KW  - Oxysterols (Other)
KW  - Survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37964298
DO  - DOI:10.1186/s12916-023-03152-7
UR  - https://inrepo02.dkfz.de/record/285388
ER  -