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@ARTICLE{Decker:285388,
      author       = {N. S. Decker$^*$ and T. Johnson$^*$ and J. A. Vey and C. Le
                      Cornet$^*$ and S. Behrens$^*$ and N. Obi and R. Kaaks$^*$
                      and J. Chang-Claude$^*$ and R. Turzanski-Fortner$^*$},
      title        = {{C}irculating oxysterols and prognosis among women with a
                      breast cancer diagnosis: results from the {MARIE} patient
                      cohort.},
      journal      = {BMC medicine},
      volume       = {21},
      number       = {1},
      issn         = {1741-7015},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-02355},
      pages        = {438},
      year         = {2023},
      note         = {#EA:C020#LA:C020#},
      abstract     = {Breast cancer is the most commonly diagnosed cancer in
                      women worldwide, and underlying mechanistic pathways
                      associated with breast cancer-specific and non-breast
                      cancer-related deaths are of importance. Emerging evidence
                      suggests a role of oxysterols, derivates of cholesterol, in
                      multiple chronic diseases including breast cancer and
                      coronary artery diseases. However, associations between
                      oxysterols and survival have been minimally studied in women
                      diagnosed with breast cancer. In this large breast cancer
                      patient cohort, we evaluated associations between a panel of
                      circulating oxysterols and mortality and recurrence
                      outcomes.Concentrations of 13 circulating oxysterols
                      representing different pathways of cholesterol metabolism
                      were quantified using liquid-chromatography
                      mass-spectrometry. Associations between baseline levels of
                      oxysterols and cause-specific mortality outcomes and
                      recurrence following a breast cancer diagnosis were assessed
                      in 2282 women from the MARIE study over a median follow-up
                      time of 11 years. We calculated hazard ratios (HR) and
                      $95\%$ confidence intervals (CI) using multivariable Cox
                      proportional hazard models and competing risks models.We
                      observed no associations for circulating oxysterols and
                      breast cancer-specific outcomes. Higher levels of six
                      oxysterols were associated with an increased risk of
                      cardiovascular disease death, including
                      24S-hydroxycholesterol (alternative bile acid pathway,
                      HRlog2 = 1.73 (1.02, 2.93)), lanosterol (cholesterol
                      biosynthesis pathway, HRlog2 = 1.95 (1.34, 2.83)),
                      7-ketocholesterol (HRlog2 = 1.26 (1.03, 1.55)),
                      5α,6α-epoxycholesterol (HRlog2 = 1.34 (1.02-1.77)), and
                      5a,6β-dihydroxycholestanol (HRlog2 = 1.34 (1.03, 1.76)).
                      After adjusting for multiple comparisons, none of the
                      associations were statistically significant.We provide first
                      evidence on a range of circulating oxysterols and mortality
                      following a breast cancer diagnosis, contributing to a
                      better understanding of associations between different
                      pathways of cholesterol metabolism and prognosis in women
                      with a breast cancer diagnosis. The findings of this study
                      suggest circulating oxysterols may be associated with
                      cardiovascular mortality among women diagnosed with breast
                      cancer. Further studies are needed to evaluate these
                      oxysterols as potential markers of risk for cardiovascular
                      mortality among women with a breast cancer diagnosis as well
                      as their clinical potential.},
      keywords     = {Breast cancer (Other) / Cancer death (Other) /
                      Cardiovascular death (Other) / Cholesterol metabolism
                      (Other) / Cohort study (Other) / Molecular epidemiology
                      (Other) / Oxysterols (Other) / Survival (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37964298},
      doi          = {10.1186/s12916-023-03152-7},
      url          = {https://inrepo02.dkfz.de/record/285388},
}