TY  - JOUR
AU  - Najafian Jazi, Maryam
AU  - Tymorek, Adrian
AU  - Yen, Ting-Yun
AU  - Jose Kavarayil, Felix
AU  - Stingl, Moritz
AU  - Chau, Sherman Richard
AU  - Baskurt, Benay
AU  - García Vilela, Celia
AU  - Allen, Kevin
TI  - Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior.
JO  - Nature Communications
VL  - 14
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2023-02365
SP  - 7373
PY  - 2023
N1  - #EA:A230#
AB  - Homing based on path integration (H-PI) is a form of navigation in which an animal uses self-motion cues to keep track of its position and return to a starting point. Despite evidence for a role of the hippocampus in homing behavior, the hippocampal spatial representations associated with H-PI are largely unknown. Here we developed a homing task (AutoPI task) that required a mouse to find a randomly placed lever on an arena before returning to its home base. Recordings from the CA1 area in male mice showed that hippocampal neurons remap between random foraging and AutoPI task, between trials in light and dark conditions, and between search and homing behavior. During the AutoPI task, approximately 25
LB  - PUB:(DE-HGF)16
C6  - pmid:37968268
DO  - DOI:10.1038/s41467-023-42642-3
UR  - https://inrepo02.dkfz.de/record/285420
ER  -