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| 001 | 285421 | ||
| 005 | 20240229155109.0 | ||
| 024 | 7 | _ | |a 10.1126/scitranslmed.adh9562 |2 doi |
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| 037 | _ | _ | |a DKFZ-2023-02366 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Meng, Zibo |0 P:(DE-He78)a7ebe54d5cb6cfa15c663da9ce1f9ab2 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Transcriptome-based identification of tumor-reactive and bystander CD8+ T cell receptor clonotypes in human pancreatic cancer. |
| 260 | _ | _ | |a Washington, DC |c 2023 |b AAAS |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1700484749_7064 |2 PUB:(DE-HGF) |
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| 500 | _ | _ | |a #EA:D200#EA:D170#LA:D200#LA:D170# / HI-TRON |
| 520 | _ | _ | |a Pancreatic ductal adenocarcinoma (PDAC) is generally refractory to immune checkpoint blockade, although patients with genetically unstable tumors can show modest therapeutic benefit. We previously demonstrated the presence of tumor-reactive CD8+ T cells in PDAC samples. Here, we charted the tumor-infiltrating T cell repertoire in PDAC by combining single-cell transcriptomics with functional testing of T cell receptors (TCRs) for reactivity against autologous tumor cells. On the basis of a comprehensive dataset including 93 tumor-reactive and 65 bystander TCR clonotypes, we delineated a gene signature that effectively distinguishes between these T cell subsets in PDAC, as well as in other tumor indications. This revealed a high frequency of tumor-reactive TCR clonotypes in three genetically unstable samples. In contrast, the T cell repertoire in six genetically stable PDAC tumors was largely dominated by bystander T cells. Nevertheless, multiple tumor-reactive TCRs were successfully identified in each of these samples, thereby providing a perspective for personalized immunotherapy in this treatment-resistant indication. |
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| 700 | 1 | _ | |a Rodriguez Ehrenfried, Aaron |0 P:(DE-He78)c083248353e32708b98dc20cb621c06a |b 1 |e First author |u dkfz |
| 700 | 1 | _ | |a Tan, Chin Leng |0 P:(DE-He78)c78afd4e9332b1120bda149010bb3633 |b 2 |e First author |u dkfz |
| 700 | 1 | _ | |a Steffens, Laura Katharina |0 P:(DE-He78)fec6ef4ffbd92f019f904ba6809ec1b3 |b 3 |u dkfz |
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| 700 | 1 | _ | |a Schwab, Marius |0 P:(DE-He78)41e96a40f6e5f7646b88ead1a776e077 |b 8 |u dkfz |
| 700 | 1 | _ | |a Förster, Jonas |0 P:(DE-He78)1dfe5fa05989d8b5eeb8bd098e2f1c1f |b 9 |u dkfz |
| 700 | 1 | _ | |a Salek, Mogjiborahman |0 P:(DE-He78)154b320ef9a6e95f0081a85ef24eb3a3 |b 10 |
| 700 | 1 | _ | |a Riemer, Angelika |0 P:(DE-He78)3743a1b712edca2ffa829b7096d7037e |b 11 |u dkfz |
| 700 | 1 | _ | |a Wu, Heshui |b 12 |
| 700 | 1 | _ | |a Eckert, Christoph |b 13 |
| 700 | 1 | _ | |a Leonhardt, Carl-Stephan |b 14 |
| 700 | 1 | _ | |a Strobel, Oliver |b 15 |
| 700 | 1 | _ | |a Volkmar, Michael |0 P:(DE-He78)792fd96345efded9a78c902105479a68 |b 16 |u dkfz |
| 700 | 1 | _ | |a Poschke, Isabel |0 P:(DE-He78)e9c55f46b4b06cf835834ee7e3e00db8 |b 17 |e Last author |u dkfz |
| 700 | 1 | _ | |a Offringa, Rienk |0 P:(DE-He78)81ae96953d6149e4307057d71a190019 |b 18 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1126/scitranslmed.adh9562 |g Vol. 15, no. 722, p. eadh9562 |0 PERI:(DE-600)2518839-2 |n 722 |p eadh9562 |t Science translational medicine |v 15 |y 2023 |x 1946-6234 |
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