%0 Journal Article
%A Reinikainen, Jaakko
%A Kuulasmaa, Kari
%A Oskarsson, Viktor
%A Amouyel, Philippe
%A Biasch, Katia
%A Brenner, Hermann
%A De Ponti, Roberto
%A Donfrancesco, Chiara
%A Drygas, Wojciech
%A Ferrieres, Jean
%A Grassi, Guido
%A Grimsgaard, Sameline
%A Iacoviello, Licia
%A Jousilahti, Pekka
%A Kårhus, Line L
%A Kee, Frank
%A Linneberg, Allan
%A Luksiene, Dalia
%A Mariño, Joany
%A Moitry, Marie
%A Palmieri, Luigi
%A Peters, Annette
%A Piwonska, Aleksandra
%A Quarti-Trevano, Fosca
%A Salomaa, Veikko
%A Sans, Susana
%A Schmidt, Carsten Oliver
%A Schöttker, Ben
%A Söderberg, Stefan
%A Tamosiunas, Abdonas
%A Thorand, Barbara
%A Tunstall-Pedoe, Hugh
%A Vanuzzo, Diego
%A Veronesi, Giovanni
%A Woodward, Mark
%A Lekadir, Karim
%A Niiranen, Teemu
%T Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors: An analysis of 49 cohorts from 11 European countries.
%J European journal of preventive cardiology
%V 31
%N 5
%@ 2047-4873
%C Oxford
%I Oxford University Press
%M DKFZ-2023-02389
%P 569-577
%D 2024
%Z 2024 Mar 27;31(5):569-577
%X The regional and temporal differences in the associations between cardiovascular disease (CVD) and its classic risk factors are unknown. The current study examined these associations in different European regions over a 30-year period.The study sample comprised 553818 individuals from 49 cohorts in 11 European countries (baseline: 1982-2012) who were followed up for a maximum of 10 years. Risk factors (sex, smoking, diabetes, non-HDL [high-density lipoprotein] cholesterol, systolic blood pressure [BP], and body mass index [BMI]) and CVD events (coronary heart disease or stroke) were harmonized across cohorts. Risk factor-outcome associations were analysed using multivariable-adjusted Cox regression models, and differences in associations were assessed using meta-regression.The differences in the risk factor-CVD associations between central Europe, northern Europe, southern Europe, and the United Kingdom were generally small. Men had a slightly higher hazard ratio (HR) in southern Europe (p = 0.043 for overall difference) and those with diabetes had a slightly lower HR in central Europe (p = 0.022 for overall difference) compared with the other regions. Of the six CVD risk factors, minor HR decreases per decade were observed for non-HDL cholesterol (7
%K Cardiovascular disease (Other)
%K Coronary heart disease (Other)
%K Europe (Other)
%K Risk factor (Other)
%K Stroke (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37976098
%R 10.1093/eurjpc/zwad359
%U https://inrepo02.dkfz.de/record/285455