TY  - JOUR
AU  - Reinikainen, Jaakko
AU  - Kuulasmaa, Kari
AU  - Oskarsson, Viktor
AU  - Amouyel, Philippe
AU  - Biasch, Katia
AU  - Brenner, Hermann
AU  - De Ponti, Roberto
AU  - Donfrancesco, Chiara
AU  - Drygas, Wojciech
AU  - Ferrieres, Jean
AU  - Grassi, Guido
AU  - Grimsgaard, Sameline
AU  - Iacoviello, Licia
AU  - Jousilahti, Pekka
AU  - Kårhus, Line L
AU  - Kee, Frank
AU  - Linneberg, Allan
AU  - Luksiene, Dalia
AU  - Mariño, Joany
AU  - Moitry, Marie
AU  - Palmieri, Luigi
AU  - Peters, Annette
AU  - Piwonska, Aleksandra
AU  - Quarti-Trevano, Fosca
AU  - Salomaa, Veikko
AU  - Sans, Susana
AU  - Schmidt, Carsten Oliver
AU  - Schöttker, Ben
AU  - Söderberg, Stefan
AU  - Tamosiunas, Abdonas
AU  - Thorand, Barbara
AU  - Tunstall-Pedoe, Hugh
AU  - Vanuzzo, Diego
AU  - Veronesi, Giovanni
AU  - Woodward, Mark
AU  - Lekadir, Karim
AU  - Niiranen, Teemu
TI  - Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors: An analysis of 49 cohorts from 11 European countries.
JO  - European journal of preventive cardiology
VL  - 31
IS  - 5
SN  - 2047-4873
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2023-02389
SP  - 569-577
PY  - 2024
N1  - 2024 Mar 27;31(5):569-577
AB  - The regional and temporal differences in the associations between cardiovascular disease (CVD) and its classic risk factors are unknown. The current study examined these associations in different European regions over a 30-year period.The study sample comprised 553818 individuals from 49 cohorts in 11 European countries (baseline: 1982-2012) who were followed up for a maximum of 10 years. Risk factors (sex, smoking, diabetes, non-HDL [high-density lipoprotein] cholesterol, systolic blood pressure [BP], and body mass index [BMI]) and CVD events (coronary heart disease or stroke) were harmonized across cohorts. Risk factor-outcome associations were analysed using multivariable-adjusted Cox regression models, and differences in associations were assessed using meta-regression.The differences in the risk factor-CVD associations between central Europe, northern Europe, southern Europe, and the United Kingdom were generally small. Men had a slightly higher hazard ratio (HR) in southern Europe (p = 0.043 for overall difference) and those with diabetes had a slightly lower HR in central Europe (p = 0.022 for overall difference) compared with the other regions. Of the six CVD risk factors, minor HR decreases per decade were observed for non-HDL cholesterol (7
KW  - Cardiovascular disease (Other)
KW  - Coronary heart disease (Other)
KW  - Europe (Other)
KW  - Risk factor (Other)
KW  - Stroke (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37976098
DO  - DOI:10.1093/eurjpc/zwad359
UR  - https://inrepo02.dkfz.de/record/285455
ER  -