%0 Journal Article
%A Zbýň, Štefan
%A Ludwig, Kai D
%A Watkins, Lauren E
%A Lagore, Russell L
%A Nowacki, Amanda
%A Tóth, Ferenc
%A Tompkins, Marc A
%A Zhang, Lin
%A Adriany, Gregor
%A Gold, Garry E
%A Shea, Kevin G
%A Nagel, Armin
%A Carlson, Cathy S
%A Metzger, Gregory J
%A Ellermann, Jutta M
%T Changes in tissue sodium concentration and sodium relaxation times during the maturation of human knee cartilage: Ex vivo 23 Na MRI study at 10.5 T.
%J Magnetic resonance in medicine
%V 91
%N 3
%@ 1522-2594
%C New York, NY [u.a.]
%I Wiley-Liss
%M DKFZ-2023-02445
%P 1099-1114
%D 2024
%Z 2024 Mar;91(3):1099-1114
%X To evaluate the influence of skeletal maturation on sodium (23 Na) MRI relaxation parameters and the accuracy of tissue sodium concentration (TSC) quantification in human knee cartilage.Twelve pediatric knee specimens were imaged with whole-body 10.5 T MRI using a density-adapted 3D radial projection sequence to evaluate 23 Na parameters: B1 + , T1 , biexponential T 2 * 
%X <br clear="all" /><table border="0" width="100%"><tr><td>
%X <table align="center" cellspacing="0"  cellpadding="2"><tr><td nowrap="nowrap" align="center">
%X  T<sub>2</sub><sup>∗</sup> </td></tr></table>
%X </td></tr></table>
%X 
%X  , and TSC. Water, collagen, and sulfated glycosaminoglycan (sGAG) content were calculated from osteochondral biopsies. The TSC was corrected for B1 + , relaxation, and water content. The literature-based TSC (TSCLB ) used previously published values for corrections, whereas the specimen-specific TSC (TSCSP ) used measurements from individual specimens. 23 Na parameters were evaluated in eight cartilage compartments segmented on proton images. Associations between 23 Na parameters, TSCLB - TSCSP difference, biochemical content, and age were determined.From birth to 12 years, cartilage water content decreased by 18
%K 10.5 T (Other)
%K 23Na relaxation parameters (Other)
%K biochemical composition of cartilage (Other)
%K knee cartilage maturation (Other)
%K sodium (23Na) MRI (Other)
%K tissue sodium concentration (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37997011
%R DOI:10.1002/mrm.29930
%U https://inrepo02.dkfz.de/record/285583