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@ARTICLE{MetzkesNg:285585,
      author       = {J. Metzkes-Ng and F.-E. Brack and F. Kroll and C. Bernert
                      and S. Bock and E. Bodenstein and M. Brand and T. E. Cowan
                      and R. Gebhardt and S. Hans and U. Helbig and F. Horst and
                      J. Jansen$^*$ and S. D. Kraft and M. Krause$^*$ and E.
                      Leßmann and S. Löck$^*$ and J. Pawelke and T. Püschel and
                      M. Reimold and M. Rehwald and C. Richter$^*$ and H.-P.
                      Schlenvoigt and U. Schramm and M. Schürer and J. Seco$^*$
                      and E. R. Szabó and M. E. P. Umlandt and K. Zeil and T.
                      Ziegler and E. Beyreuther},
      title        = {{T}he {DRESDEN} {PLATFORM} is a research hub for ultra-high
                      dose rate radiobiology.},
      journal      = {Scientific reports},
      volume       = {13},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2023-02447},
      pages        = {20611},
      year         = {2023},
      abstract     = {The recently observed FLASH effect describes the
                      observation of normal tissue protection by ultra-high dose
                      rates (UHDR), or dose delivery in a fraction of a second, at
                      similar tumor-killing efficacy of conventional dose delivery
                      and promises great benefits for radiotherapy patients.
                      Dedicated studies are now necessary to define a robust set
                      of dose application parameters for FLASH radiotherapy and to
                      identify underlying mechanisms. These studies require
                      particle accelerators with variable temporal dose
                      application characteristics for numerous radiation
                      qualities, equipped for preclinical radiobiological
                      research. Here we present the DRESDEN PLATFORM, a research
                      hub for ultra-high dose rate radiobiology. By uniting
                      clinical and research accelerators with radiobiology
                      infrastructure and know-how, the DRESDEN PLATFORM offers a
                      unique environment for studying the FLASH effect. We
                      introduce its experimental capabilities and demonstrate the
                      platform's suitability for systematic investigation of FLASH
                      by presenting results from a concerted in vivo radiobiology
                      study with zebrafish embryos. The comparative pre-clinical
                      study was conducted across one electron and two proton
                      accelerator facilities, including an advanced laser-driven
                      proton source applied for FLASH-relevant in vivo
                      irradiations for the first time. The data show a protective
                      effect of UHDR irradiation up to [Formula: see text] and
                      suggests consistency of the protective effect even at
                      escalated dose rates of [Formula: see text]. With the first
                      clinical FLASH studies underway, research facilities like
                      the DRESDEN PLATFORM, addressing the open questions
                      surrounding FLASH, are essential to accelerate FLASH's
                      translation into clinical practice.},
      cin          = {E041 / DD01},
      ddc          = {600},
      cid          = {I:(DE-He78)E041-20160331 / I:(DE-He78)DD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37996453},
      doi          = {10.1038/s41598-023-46873-8},
      url          = {https://inrepo02.dkfz.de/record/285585},
}