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| 001 | 285587 | ||
| 005 | 20240229155114.0 | ||
| 024 | 7 | _ | |a 10.1038/s43018-023-00668-y |2 doi |
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| 037 | _ | _ | |a DKFZ-2023-02449 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ghasemi, Ali |b 0 |
| 245 | _ | _ | |a Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy. |
| 260 | _ | _ | |a London |c 2024 |b Nature Research |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
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| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2024 Feb;5(2):240-261 |
| 520 | _ | _ | |a Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical results. Here, we present a cell-therapy platform based on mouse or human DC progenitors (DCPs) engineered to produce two immunostimulatory cytokines, IL-12 and FLT3L. Cytokine-armed DCPs differentiated into conventional type-I DCs (cDC1) and suppressed tumor growth, including melanoma and autochthonous liver models, without the need for antigen loading or myeloablative host conditioning. Tumor response involved synergy between IL-12 and FLT3L and was associated with natural killer and T cell infiltration and activation, M1-like macrophage programming and ischemic tumor necrosis. Antitumor immunity was dependent on endogenous cDC1 expansion and interferon-γ signaling but did not require CD8+ T cell cytotoxicity. Cytokine-armed DCPs synergized effectively with anti-GD2 chimeric-antigen receptor (CAR) T cells in eradicating intracranial gliomas in mice, illustrating their potential in combination therapies. |
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| 700 | 1 | _ | |a Martinez-Usatorre, Amaia |0 0000-0002-3416-1529 |b 1 |
| 700 | 1 | _ | |a Li, Luqing |b 2 |
| 700 | 1 | _ | |a Hicham, Mehdi |0 0000-0002-9979-4757 |b 3 |
| 700 | 1 | _ | |a Guichard, Alan |0 0000-0001-8623-9570 |b 4 |
| 700 | 1 | _ | |a Marcone, Rachel |b 5 |
| 700 | 1 | _ | |a Fournier, Nadine |0 0000-0002-9347-7929 |b 6 |
| 700 | 1 | _ | |a Torchia, Bruno |b 7 |
| 700 | 1 | _ | |a Martinez Bedoya, Darel |0 0000-0002-1603-5801 |b 8 |
| 700 | 1 | _ | |a Davanture, Suzel |b 9 |
| 700 | 1 | _ | |a Fernández-Vaquero, Mirian |b 10 |
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| 700 | 1 | _ | |a Mohammadzadeh, Yahya |b 13 |
| 700 | 1 | _ | |a Genolet, Raphael |b 14 |
| 700 | 1 | _ | |a Mansouri, Nahal |b 15 |
| 700 | 1 | _ | |a Wenes, Mathias |0 0000-0001-8478-8592 |b 16 |
| 700 | 1 | _ | |a Migliorini, Denis |0 0000-0003-0151-3222 |b 17 |
| 700 | 1 | _ | |a Heikenwälder, Mathias |0 P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5 |b 18 |u dkfz |
| 700 | 1 | _ | |a De Palma, Michele |0 0000-0001-9128-5459 |b 19 |
| 773 | _ | _ | |a 10.1038/s43018-023-00668-y |0 PERI:(DE-600)3005299-3 |n 2 |p 240-261 |t Nature cancer |v 5 |y 2024 |x 2662-1347 |
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