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@ARTICLE{Morais:285591,
      author       = {S. Morais and M. D. Wissing and F. Khosrow-Khavar and A. N.
                      Burchell and P.-P. Tellier and F. Coutlée and T.
                      Waterboer$^*$ and M. El-Zein and E. L. Franco},
      title        = {{S}erologic response to human papillomavirus genotypes
                      following vaccination: findings from the {HITCH} cohort
                      study.},
      journal      = {Infectious diseases},
      volume       = {56},
      number       = {1},
      issn         = {2374-4235},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2023-02453},
      pages        = {66-72},
      year         = {2024},
      note         = {2024 Jan;56(1):66-72},
      abstract     = {Human papillomavirus (HPV) infection contributes to
                      approximately $5\%$ of the worldwide cancer burden. The
                      three-dose HPV vaccine has demonstrated immunogenicity and
                      efficacy. Humoral responses may be critical for preventing,
                      controlling, and/or eliminating HPV infection. Using data
                      from the HITCH cohort, we analysed humoral immune response
                      to HPV vaccination among women in relation to the
                      phylogenetic relatedness of HPV genotypes.We included 96
                      women aged 18-24 years attending college or university in
                      Montreal, Canada. Participants provided blood samples at
                      enrolment and five follow-up visits. Antibody response to
                      bacterially expressed L1 and E6 glutathione S-transferase
                      fusion proteins of multiple Alphapapillomavirus types, and
                      to virus-like particles (VLP-L1) of HPV16 and HPV18 were
                      measured using multiplex serology. We assessed correlations
                      between antibody seroreactivities using Pearson correlations
                      (r).At enrolment, $87.7\%$ of participants were
                      unvaccinated, $2.4\%$ had received one, $3.2\%$ two, and
                      $6.7\%$ three doses of HPV vaccine. The corresponding L1
                      seropositivity to any HPV was $41.2\%,$ $83.3\%,$ $100\%,$
                      and $97.0\%.$ Between-type correlations for L1
                      seroreactivities increased with the number of vaccine doses,
                      from one to three. Among the latter, the strongest
                      correlations were observed for HPV58-HPV33 (Pearson
                      correlation [r] = 0.96; α9-species); HPV11-HPV6 (r = 0.96;
                      α10-species); HPV45-HPV18 (r = 0.95; α7-species), and
                      HPV68-HPV59 (r = 0.95; α7-species).Correlations between
                      HPV-specific antibody seroreactivities are affected by
                      phylogenetic relatedness, with anti-L1 correlations becoming
                      stronger with the number of vaccine doses received.},
      keywords     = {Antibodies (Other) / human papillomavirus (Other) /
                      immunogenicity (Other) / papillomavirus vaccines (Other) /
                      serology (Other)},
      cin          = {F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37994805},
      doi          = {10.1080/23744235.2023.2277390},
      url          = {https://inrepo02.dkfz.de/record/285591},
}