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000285670 1001_ $$0P:(DE-He78)4c6aa22ff0ca8ef5faf7abe3e9716bdf$$aAlonso de la Vega, Alicia$$b0$$eFirst author$$udkfz
000285670 245__ $$aAcute expression of human APOBEC3B in mice results in RNA editing and lethality.
000285670 260__ $$aLondon$$bBioMed Central$$c2023
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000285670 520__ $$aRNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The cytosine deaminase APOBEC3B is implicated in tumor evolution through DNA mutation, but whether it also functions as an RNA editing enzyme has not been studied.Here, we engineer a novel doxycycline-inducible mouse model of human APOBEC3B-overexpression to understand the impact of this enzyme in tissue homeostasis and address a potential role in C-to-U RNA editing. Elevated and sustained levels of APOBEC3B lead to rapid alteration of cellular fitness, major organ dysfunction, and ultimately lethality in mice. Importantly, RNA-sequencing of mouse tissues expressing high levels of APOBEC3B identifies frequent UCC-to-UUC RNA editing events that are not evident in the corresponding genomic DNA.This work identifies, for the first time, a new deaminase-dependent function for APOBEC3B in RNA editing and presents a preclinical tool to help understand the emerging role of APOBEC3B as a driver of carcinogenesis.
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000285670 650_7 $$2Other$$aAPOBEC3B
000285670 650_7 $$2Other$$aDNA damage
000285670 650_7 $$2Other$$aMouse models
000285670 650_7 $$2Other$$aMutations
000285670 650_7 $$2Other$$aRNA editing
000285670 650_7 $$0EC 3.5.4.5$$2NLM Chemicals$$aCytidine Deaminase
000285670 650_7 $$2NLM Chemicals$$aMinor Histocompatibility Antigens
000285670 650_7 $$09007-49-2$$2NLM Chemicals$$aDNA
000285670 650_7 $$0EC 3.5.4.5$$2NLM Chemicals$$aAPOBEC3B protein, human
000285670 650_2 $$2MeSH$$aHumans
000285670 650_2 $$2MeSH$$aAnimals
000285670 650_2 $$2MeSH$$aMice
000285670 650_2 $$2MeSH$$aRNA Editing
000285670 650_2 $$2MeSH$$aCytidine Deaminase: genetics
000285670 650_2 $$2MeSH$$aCytidine Deaminase: metabolism
000285670 650_2 $$2MeSH$$aMutation
000285670 650_2 $$2MeSH$$aNeoplasms: pathology
000285670 650_2 $$2MeSH$$aMinor Histocompatibility Antigens: genetics
000285670 650_2 $$2MeSH$$aMinor Histocompatibility Antigens: metabolism
000285670 650_2 $$2MeSH$$aDNA: metabolism
000285670 7001_ $$aTemiz, Nuri Alpay$$b1
000285670 7001_ $$0P:(DE-He78)65976eb710a9a31556034061f78781d5$$aTasakis, Rafail$$b2
000285670 7001_ $$0P:(DE-He78)1a99792a8cdba2d016336662bb5c1099$$aSomogyi, Kalman$$b3$$udkfz
000285670 7001_ $$0P:(DE-HGF)0$$aSalgueiro, Lorena$$b4
000285670 7001_ $$0P:(DE-He78)dd8afdb992341efdf1a1ce54d15e65f3$$aZimmer, Eleni$$b5$$udkfz
000285670 7001_ $$0P:(DE-HGF)0$$aRamos, Maria$$b6
000285670 7001_ $$0P:(DE-HGF)0$$aDiaz-Jimenez, Alberto$$b7
000285670 7001_ $$0P:(DE-HGF)0$$aChocarro, Sara$$b8
000285670 7001_ $$0P:(DE-HGF)0$$aFernández-Vaquero, Mirian$$b9
000285670 7001_ $$aStefanovska, Bojana$$b10
000285670 7001_ $$aReuveni, Eli$$b11
000285670 7001_ $$aBen-David, Uri$$b12
000285670 7001_ $$aStenzinger, Albrecht$$b13
000285670 7001_ $$aPoth, Tanja$$b14
000285670 7001_ $$0P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5$$aHeikenwälder, Mathias$$b15$$udkfz
000285670 7001_ $$0P:(DE-HGF)0$$aPapavasiliou, Nina$$b16
000285670 7001_ $$aHarris, Reuben S$$b17
000285670 7001_ $$00000-0002-0855-7917$$aSotillo, Rocio$$b18$$eLast author
000285670 773__ $$0PERI:(DE-600)2040529-7$$a10.1186/s13059-023-03115-4$$gVol. 24, no. 1, p. 267$$n1$$p267$$tGenome biology$$v24$$x1465-6906$$y2023
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