% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{AlonsodelaVega:285670,
      author       = {A. Alonso de la Vega$^*$ and N. A. Temiz and R. Tasakis$^*$
                      and K. Somogyi$^*$ and L. Salgueiro$^*$ and E. Zimmer$^*$
                      and M. Ramos$^*$ and A. Diaz-Jimenez$^*$ and S. Chocarro$^*$
                      and M. Fernández-Vaquero$^*$ and B. Stefanovska and E.
                      Reuveni and U. Ben-David and A. Stenzinger and T. Poth and
                      M. Heikenwälder$^*$ and N. Papavasiliou$^*$ and R. S.
                      Harris and R. Sotillo$^*$},
      title        = {{A}cute expression of human {APOBEC}3{B} in mice results in
                      {RNA} editing and lethality.},
      journal      = {Genome biology},
      volume       = {24},
      number       = {1},
      issn         = {1465-6906},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2023-02493},
      pages        = {267},
      year         = {2023},
      note         = {#EA:B220#LA:B220#},
      abstract     = {RNA editing has been described as promoting genetic
                      heterogeneity, leading to the development of multiple
                      disorders, including cancer. The cytosine deaminase APOBEC3B
                      is implicated in tumor evolution through DNA mutation, but
                      whether it also functions as an RNA editing enzyme has not
                      been studied.Here, we engineer a novel doxycycline-inducible
                      mouse model of human APOBEC3B-overexpression to understand
                      the impact of this enzyme in tissue homeostasis and address
                      a potential role in C-to-U RNA editing. Elevated and
                      sustained levels of APOBEC3B lead to rapid alteration of
                      cellular fitness, major organ dysfunction, and ultimately
                      lethality in mice. Importantly, RNA-sequencing of mouse
                      tissues expressing high levels of APOBEC3B identifies
                      frequent UCC-to-UUC RNA editing events that are not evident
                      in the corresponding genomic DNA.This work identifies, for
                      the first time, a new deaminase-dependent function for
                      APOBEC3B in RNA editing and presents a preclinical tool to
                      help understand the emerging role of APOBEC3B as a driver of
                      carcinogenesis.},
      keywords     = {Humans / Animals / Mice / RNA Editing / Cytidine Deaminase:
                      genetics / Cytidine Deaminase: metabolism / Mutation /
                      Neoplasms: pathology / Minor Histocompatibility Antigens:
                      genetics / Minor Histocompatibility Antigens: metabolism /
                      DNA: metabolism / APOBEC3B (Other) / DNA damage (Other) /
                      Mouse models (Other) / Mutations (Other) / RNA editing
                      (Other) / Cytidine Deaminase (NLM Chemicals) / Minor
                      Histocompatibility Antigens (NLM Chemicals) / DNA (NLM
                      Chemicals) / APOBEC3B protein, human (NLM Chemicals)},
      cin          = {B220 / F180 / D150},
      ddc          = {570},
      cid          = {I:(DE-He78)B220-20160331 / I:(DE-He78)F180-20160331 /
                      I:(DE-He78)D150-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38001542},
      pmc          = {pmc:PMC10668425},
      doi          = {10.1186/s13059-023-03115-4},
      url          = {https://inrepo02.dkfz.de/record/285670},
}