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000285678 0247_ $$2ISSN$$a1361-6560
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000285678 1001_ $$00000-0001-5719-7105$$aAbouzahr, F.$$b0
000285678 245__ $$aThe first probe of a FLASH proton beam by PET.
000285678 260__ $$aBristol$$bIOP Publ.$$c2023
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000285678 520__ $$aThe recently observed FLASH effect related to high doses delivered with high rates has the potential to revolutionize radiation cancer therapy if promising results are confirmed and an underlying mechanism understood. Comprehensive measurements are essential to elucidate the phenomenon. We report the first-ever demonstration of measurements of successive in-spill and post-spill emissions of gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography (PET) system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson Cancer Center to view phantoms irradiated by 3.5 × 1010protons with a kinetic energy of 75.8 MeV delivered in 101.5 ms-long spills yielding a dose rate of 164 Gy s-1. Most in-spill events were due to prompt gammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitative imaging and dosimetric information. These findings open a new and novel modality for imaging and monitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by post-spill PET imaging.
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000285678 650_7 $$2Other$$aFLASH
000285678 650_7 $$2Other$$aPET
000285678 650_7 $$2Other$$aPET dosimetry
000285678 650_7 $$2Other$$aPET imaging
000285678 650_7 $$2Other$$aProton therapy
000285678 650_7 $$2Other$$aprompt gammas
000285678 650_7 $$2NLM Chemicals$$aProtons
000285678 650_2 $$2MeSH$$aProtons
000285678 650_2 $$2MeSH$$aProton Therapy: methods
000285678 650_2 $$2MeSH$$aPositron-Emission Tomography
000285678 650_2 $$2MeSH$$aRadiometry
000285678 650_2 $$2MeSH$$aPhantoms, Imaging
000285678 7001_ $$00000-0001-6644-0023$$aCesar, J. P.$$b1
000285678 7001_ $$00000-0002-0891-032X$$aCrespo, P.$$b2
000285678 7001_ $$00009-0002-2147-0848$$aGajda, M.$$b3
000285678 7001_ $$aHu, Z.$$b4
000285678 7001_ $$aKlein, K.$$b5
000285678 7001_ $$00009-0005-6205-9512$$aKuo, A. S.$$b6
000285678 7001_ $$aMajewski, S.$$b7
000285678 7001_ $$00000-0003-4446-5670$$aMawlawi, O.$$b8
000285678 7001_ $$aMorozov, A.$$b9
000285678 7001_ $$00009-0004-8148-3012$$aOjha, A.$$b10
000285678 7001_ $$aPoenisch, F.$$b11
000285678 7001_ $$00000-0002-0303-5159$$aProga, M.$$b12
000285678 7001_ $$00000-0003-1497-4327$$aSahoo, N.$$b13
000285678 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b14$$udkfz
000285678 7001_ $$aTakaoka, T.$$b15
000285678 7001_ $$00000-0002-6792-9522$$aTavernier, S.$$b16
000285678 7001_ $$00000-0001-6555-4977$$aTitt, U.$$b17
000285678 7001_ $$aWang, X.$$b18
000285678 7001_ $$aZhu, X. R.$$b19
000285678 7001_ $$aLang, K.$$b20
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