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@ARTICLE{Sepp:285694,
      author       = {M. Sepp and K. Leiss and F. Murat and K. Okonechnikov$^*$
                      and P. K. Joshi$^*$ and E. Leushkin and L. Spänig$^*$ and
                      N. Mbengue and C. Schneider and J. Schmidt and N. Trost and
                      M. Schauer and P. Khaitovich and S. Lisgo and M. Palkovits
                      and P. Giere and L. Kutscher$^*$ and S. Anders and M.
                      Cardoso-Moreira and I. Sarropoulos and S. Pfister$^*$ and H.
                      Kaessmann},
      title        = {{C}ellular development and evolution of the mammalian
                      cerebellum.},
      journal      = {Nature},
      volume       = {625},
      number       = {7996},
      issn         = {0028-0836},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-02509},
      pages        = {788-796},
      year         = {2024},
      note         = {DKFZ-ZMBH Alliance / #LA:B062# / 2024
                      Jan;625(7996):788-796},
      abstract     = {The expansion of the neocortex, a hallmark of mammalian
                      evolution1,2, was accompanied by an increase in cerebellar
                      neuron numbers3. However, little is known about the
                      evolution of the cellular programs underlying cerebellum
                      development in mammals. In this study, we generated
                      single-nucleus RNA-sequencing data for ~400,000 cells to
                      trace cerebellum development from early neurogenesis to
                      adulthood in human, mouse, and the marsupial opossum. We
                      established a consensus classification of the cellular
                      diversity in the developing mammalian cerebellum and
                      validated it by spatial mapping in the fetal human
                      cerebellum. Our cross-species analyses revealed a largely
                      conserved developmental dynamics of cell type generation,
                      except for Purkinje cells, where we observed an expansion of
                      early-born subtypes in the human lineage. Global
                      transcriptome profiles, conserved cell state markers, and
                      gene expression trajectories across neuronal differentiation
                      show that cerebellar cell type-defining programs have been
                      overall preserved for at least ~160 million years. However,
                      we also identified many orthologous genes that gained or
                      lost expression in cerebellar neural cell types in one of
                      the species, or evolved new expression trajectories during
                      neuronal differentiation, indicating widespread gene
                      repurposing at the cell type level. Altogether, our study
                      unveils shared and lineage-specific gene expression programs
                      governing the development of cerebellar cells, and expands
                      our understanding of mammalian brain evolution.},
      cin          = {B062 / HD01 / B430},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B430-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38029793},
      doi          = {10.1038/s41586-023-06884-x},
      url          = {https://inrepo02.dkfz.de/record/285694},
}