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000285710 1001_ $$00000-0002-1317-7847$$aLago, Chiara$$b0
000285710 245__ $$aPatient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments.
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000285710 500__ $$a#LA:B062# / 2023 Dec 7;15(12):e18199
000285710 520__ $$aBrain tumors are the leading cause of cancer-related death in children. Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of pediatric brain cancers are limited and hard to establish. We present a protocol that enables efficient generation, expansion, and biobanking of pediatric brain cancer organoids. Utilizing our protocol, we have established patient-derived organoids (PDOs) from ependymomas, medulloblastomas, low-grade glial tumors, and patient-derived xenograft organoids (PDXOs) from medulloblastoma xenografts. PDOs and PDXOs recapitulate histological features, DNA methylation profiles, and intratumor heterogeneity of the tumors from which they were derived. We also showed that PDOs can be xenografted. Most interestingly, when subjected to the same routinely applied therapeutic regimens, PDOs respond similarly to the patients. Taken together, our study highlights the potential of PDOs and PDXOs for research and translational applications for personalized medicine.
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000285710 650_7 $$2Other$$abrain tumors
000285710 650_7 $$2Other$$aorganoids
000285710 650_7 $$2Other$$apatient-derived
000285710 650_7 $$2Other$$apediatric cancer
000285710 650_7 $$2Other$$atranslational applications
000285710 7001_ $$0P:(DE-He78)32c5110cd42ee8a96b18a3e8909bd0a9$$aFederico, Aniello$$b1$$udkfz
000285710 7001_ $$00000-0003-1147-700X$$aLeva, Gloria$$b2
000285710 7001_ $$0P:(DE-He78)e73a0a4fab40344d89d693cbe1df3109$$aMack, Norman L$$b3$$udkfz
000285710 7001_ $$0P:(DE-He78)9ce969bf1ac7913b3f2b1cf4dd7f823e$$aSchwalm, Benjamin$$b4$$udkfz
000285710 7001_ $$00000-0001-6632-1489$$aBallabio, Claudio$$b5
000285710 7001_ $$00000-0002-8976-6883$$aGianesello, Matteo$$b6
000285710 7001_ $$aAbballe, Luana$$b7
000285710 7001_ $$00000-0002-9980-6594$$aGiovannoni, Isabella$$b8
000285710 7001_ $$aReddel, Sofia$$b9
000285710 7001_ $$aRossi, Sabrina$$b10
000285710 7001_ $$00000-0003-1494-5411$$aLeone, Nicolas$$b11
000285710 7001_ $$aCarai, Andrea$$b12
000285710 7001_ $$aMastronuzzi, Angela$$b13
000285710 7001_ $$00000-0002-3326-1923$$aBisio, Alessandra$$b14
000285710 7001_ $$00000-0002-3120-9929$$aSoldano, Alessia$$b15
000285710 7001_ $$aQuintarelli, Concetta$$b16
000285710 7001_ $$00000-0002-7976-3654$$aLocatelli, Franco$$b17
000285710 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b18$$eLast author$$udkfz
000285710 7001_ $$00000-0002-4747-1032$$aMiele, Evelina$$b19
000285710 7001_ $$00000-0002-5983-3782$$aTiberi, Luca$$b20
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