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@ARTICLE{Lucien:286010,
      author       = {F. Lucien and D. Gustafson and M. Lenassi and B. Li and J.
                      J. Teske and E. Boilard and K. C. von Hohenberg$^*$ and J.
                      M. Falcón-Perez and A. Gualerzi and A. Reale and J. C.
                      Jones and C. Lässer and C. Lawson and I. Nazarenko$^*$ and
                      L. O'Driscoll and R. Pink and P. R. Siljander and C.
                      Soekmadji and A. Hendrix and J. A. Welsh and K. W. Witwer
                      and R. Nieuwland},
      title        = {{MIB}lood-{EV}: {M}inimal information to enhance the
                      quality and reproducibility of blood extracellular vesicle
                      research.},
      journal      = {Journal of extracellular vesicles},
      volume       = {12},
      number       = {12},
      issn         = {2001-3078},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-02587},
      pages        = {12385},
      year         = {2023},
      abstract     = {Blood is the most commonly used body fluid for
                      extracellular vesicle (EV) research. The composition of a
                      blood sample and its derivatives (i.e., plasma and serum)
                      are not only donor-dependent but also influenced by
                      collection and preparation protocols. Since there are
                      hundreds of pre-analytical protocols and over forty
                      variables, the development of standard operating procedures
                      for EV research is very challenging. To improve the
                      reproducibility of blood EV research, the International
                      Society for Extracellular Vesicles (ISEV) Blood EV Task
                      Force proposes standardized reporting of (i) the applied
                      blood collection and preparation protocol and (ii) the
                      quality of the prepared plasma and serum samples. Gathering
                      detailed information will provide insight into the
                      performance of the protocols and more effectively identify
                      potential confounders in the prepared plasma and serum
                      samples. To collect this information, the ISEV Blood EV Task
                      Force created the Minimal Information for Blood EV research
                      (MIBlood-EV), a tool to record and report information about
                      pre-analytical protocols used for plasma and serum
                      preparation as well as assays used to assess the quality of
                      these preparations. This tool does not require modifications
                      of established local pre-analytical protocols and can be
                      easily implemented to enhance existing databases thereby
                      enabling evidence-based optimization of pre-analytical
                      protocols through meta-analysis. Taken together, insight
                      into the quality of prepared plasma and serum samples will
                      (i) improve the quality of biobanks for EV research, (ii)
                      guide the exchange of plasma and serum samples between
                      biobanks and laboratories, (iii) facilitate inter-laboratory
                      comparative EV studies, and (iv) improve the peer review
                      process.},
      keywords     = {biomarker (Other) / blood (Other) / extracellular vesicles
                      (Other) / liquid biopsy (Other) / quality control (Other) /
                      reproducibility (Other) / standardization (Other)},
      cin          = {B470 / FR01},
      ddc          = {570},
      cid          = {I:(DE-He78)B470-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38063210},
      pmc          = {pmc:PMC10704543},
      doi          = {10.1002/jev2.12385},
      url          = {https://inrepo02.dkfz.de/record/286010},
}