TY  - JOUR
AU  - Faddegon, Bruce
AU  - Descovich, Martina
AU  - Chen, Katherine
AU  - Ramos-Méndez, José
AU  - Iii, Mack Roach
AU  - Wahl, Niklas
AU  - Taylor, Paige
AU  - Griffin, Keith
AU  - Lee, Choonsik
TI  - A digital male pelvis phantom series showing anatomical variations over the course of fractionated radiotherapy treatment.
JO  - Medical physics
VL  - 51
IS  - 4
SN  - 0094-2405
CY  - College Park, Md.
PB  - AAPM
M1  - DKFZ-2023-02600
SP  - 3034-3044
PY  - 2024
N1  - 2024 Apr;51(4):3034-3044
AB  - Daily IGRT images show day-to-day anatomical variations in patients undergoing fractionated prostate radiotherapy. This is of particular importance in particle beam treatments.To develop a digital phantom series showing variation in pelvic anatomy for evaluating treatment planning and IGRT procedures in particle radiotherapy.A pelvic phantom series was developed from the planning MRI and kVCT (planning CT) images along with six of the daily serial MVCT images taken of a single patient treated with a full bladder on a Tomotherapy unit. The selected patient had clearly visible yet unexceptional internal anatomy variation. Prostate, urethra, bladder, rectum, bowel, bowel gas, bone and soft tissue were contoured and a single Hounsfield Unit was assigned to each region. Treatment plans developed on the kVCT for photon, proton and carbon beams were recalculated on each phantom to demonstrate a clinical application of the series. Proton plans were developed with and without robust optimization.Limited to axial slices with prostate, the bladder volume varied from 6 to 46 cm3 , the rectal volume (excluding gas) from 22 to 52 cm3 , and rectal gas volume from zero to 18 cm3 . The water equivalent path length to the prostate varied by up to 1.5 cm . The variations resulted in larger changes in the RBE-weighted Dose Volume Histograms of the non-robust proton plan and the carbon plan compared to the robust proton plan, the latter similar to the photon plan. The prostate coverage (V100
KW  - interfraction motion (Other)
KW  - ion beams (Other)
KW  - pelvis phantom (Other)
KW  - prostate (Other)
KW  - protons (Other)
KW  - treatment planning (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38071746
DO  - DOI:10.1002/mp.16865
UR  - https://inrepo02.dkfz.de/record/286023
ER  -