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001     286023
005     20240414010445.0
024 7 _ |a 10.1002/mp.16865
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024 7 _ |a 0094-2405
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037 _ _ |a DKFZ-2023-02600
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Faddegon, Bruce
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245 _ _ |a A digital male pelvis phantom series showing anatomical variations over the course of fractionated radiotherapy treatment.
260 _ _ |a College Park, Md.
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336 7 _ |a Journal Article
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500 _ _ |a 2024 Apr;51(4):3034-3044
520 _ _ |a Daily IGRT images show day-to-day anatomical variations in patients undergoing fractionated prostate radiotherapy. This is of particular importance in particle beam treatments.To develop a digital phantom series showing variation in pelvic anatomy for evaluating treatment planning and IGRT procedures in particle radiotherapy.A pelvic phantom series was developed from the planning MRI and kVCT (planning CT) images along with six of the daily serial MVCT images taken of a single patient treated with a full bladder on a Tomotherapy unit. The selected patient had clearly visible yet unexceptional internal anatomy variation. Prostate, urethra, bladder, rectum, bowel, bowel gas, bone and soft tissue were contoured and a single Hounsfield Unit was assigned to each region. Treatment plans developed on the kVCT for photon, proton and carbon beams were recalculated on each phantom to demonstrate a clinical application of the series. Proton plans were developed with and without robust optimization.Limited to axial slices with prostate, the bladder volume varied from 6 to 46 cm3 , the rectal volume (excluding gas) from 22 to 52 cm3 , and rectal gas volume from zero to 18 cm3 . The water equivalent path length to the prostate varied by up to 1.5 cm . The variations resulted in larger changes in the RBE-weighted Dose Volume Histograms of the non-robust proton plan and the carbon plan compared to the robust proton plan, the latter similar to the photon plan. The prostate coverage (V100%) decreased by an average of 18% in the carbon plan, 16% in the non-robust proton plan, 1.8% in the robust proton plan, and 4.4% in the photon plan. The volume of rectum receiving 75% of the prescription dose (V75%) increased by an average of 3.7 cm3 , 4.7 cm3 , 1.9 cm3 , and 0.6 cm3 in those four plans, respectively.The digital pelvic phantom series provides for quantitative investigation of IGRT procedures and new methods for improving accuracy in particle therapy and may be used in cross-institutional comparisons for clinical trial quality assurance.
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650 _ 7 |a interfraction motion
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650 _ 7 |a ion beams
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650 _ 7 |a pelvis phantom
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650 _ 7 |a prostate
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650 _ 7 |a protons
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650 _ 7 |a treatment planning
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700 1 _ |a Descovich, Martina
|b 1
700 1 _ |a Chen, Katherine
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700 1 _ |a Ramos-Méndez, José
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700 1 _ |a Iii, Mack Roach
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700 1 _ |a Wahl, Niklas
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700 1 _ |a Taylor, Paige
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700 1 _ |a Griffin, Keith
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700 1 _ |a Lee, Choonsik
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