TY  - JOUR
AU  - Li, Xianzhe
AU  - Stassen, Lara
AU  - Schrotz-King, Petra
AU  - Zhao, Zitong
AU  - Cardoso, Rafael
AU  - Raut, Janhavi R
AU  - Bhardwaj, Megha
AU  - Brenner, Hermann
TI  - Potential of Fecal Carcinoembryonic Antigen for Noninvasive Detection of Colorectal Cancer: A Systematic Review.
JO  - Cancers
VL  - 15
IS  - 23
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-02657
SP  - 5656
PY  - 2023
N1  - #EA:C070#LA:C070#LA:C120#
AB  - Carcinoembryonic antigen (CEA) is more abundant in feces than in serum; however, evidence for the role of fecal CEA (FCEA) in the detection of colorectal cancer (CRC) is limited. We conducted a systematic review of studies that evaluated FCEA for the noninvasive detection and diagnosis of CRC. PubMed and Web of Science were searched for relevant studies published until 18 January 2023. Information on publication year, study design, country, study population characteristics, FCEA and serum CEA (SCEA) concentrations, and diagnostic performance was summarized. Two authors independently extracted data and assessed the risk of bias and applicability of each included study. Seven studies published between 1979 and 2021, all conducted in clinical settings and together involving 399 CRC patients and 889 controls, were identified. Significant differences in FCEA concentrations were observed between CRC and control groups in all studies. Methods for detecting FCEA varied, with the electronic chemiluminescence immunoassay (ECLIA) being used in the most recent studies. Reported sensitivities, specificities, and area under the curves of FCEA ranged from 50.0
KW  - carcinoembryonic antigen (Other)
KW  - colorectal cancer (Other)
KW  - diagnosis (Other)
KW  - stool (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38067360
C2  - pmc:PMC10705067
DO  - DOI:10.3390/cancers15235656
UR  - https://inrepo02.dkfz.de/record/286081
ER  -