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@ARTICLE{Timmins:286099,
      author       = {I. R. Timmins and M. E. Jones and K. M. O'Brien and H.-O.
                      Adami and D. Aune and L. Baglietto and K. A. Bertrand and K.
                      D. Brantley and Y. Chen and J. Clague DeHart and T. V.
                      Clendenen and L. Dossus and A. H. Eliassen and O. Fletcher
                      and A. Fournier and N. Håkansson and S. E. Hankinson and R.
                      S. Houlston and C. E. Joshu and V. A. Kirsh and C. M.
                      Kitahara and W.-P. Koh and M. S. Linet and H. L. Park and B.
                      M. Lynch and A. M. May and L. Mellemkjær and R. L. Milne
                      and J. R. Palmer and F. Ricceri and T. E. Rohan and K. J.
                      Ruddy and M.-J. Sánchez and X.-O. Shu and K. Smith-Byrne
                      and K. Steindorf$^*$ and M. Sund and C. M. Vachon and L. J.
                      Vatten and K. Visvanathan and E. Weiderpass and W. C.
                      Willett and A. Wolk and J.-M. Yuan and W. Zheng and H. B.
                      Nichols and D. P. Sandler and A. J. Swerdlow and M. J.
                      Schoemaker},
      title        = {{I}nternational {P}ooled {A}nalysis of {L}eisure-{T}ime
                      {P}hysical {A}ctivity and {P}remenopausal {B}reast {C}ancer
                      in {W}omen {F}rom 19 {C}ohorts.},
      journal      = {Journal of clinical oncology},
      volume       = {42},
      number       = {8},
      issn         = {0732-183X},
      address      = {Alexandria, Va.},
      publisher    = {American Society of Clinical Oncology},
      reportid     = {DKFZ-2023-02675},
      pages        = {927-939},
      year         = {2024},
      note         = {2024 Mar 10;42(8):927-939},
      abstract     = {There is strong evidence that leisure-time physical
                      activity is protective against postmenopausal breast cancer
                      risk but the association with premenopausal breast cancer is
                      less clear. The purpose of this study was to examine the
                      association of physical activity with the risk of developing
                      premenopausal breast cancer.We pooled individual-level data
                      on self-reported leisure-time physical activity across 19
                      cohort studies comprising 547,601 premenopausal women, with
                      10,231 incident cases of breast cancer. Multivariable Cox
                      regression was used to estimate hazard ratios (HRs) and
                      $95\%$ CIs for associations of leisure-time physical
                      activity with breast cancer incidence. HRs for high versus
                      low levels of activity were based on a comparison of risk at
                      the 90th versus 10th percentiles of activity. We assessed
                      the linearity of the relationship and examined
                      subtype-specific associations and effect modification across
                      strata of breast cancer risk factors, including
                      adiposity.Over a median 11.5 years of follow-up (IQR,
                      8.0-16.1 years), high versus low levels of leisure-time
                      physical activity were associated with a $6\%$ (HR, 0.94
                      $[95\%$ CI, 0.89 to 0.99]) and a $10\%$ (HR, 0.90 $[95\%$
                      CI, 0.85 to 0.95]) reduction in breast cancer risk, before
                      and after adjustment for BMI, respectively. Tests of
                      nonlinearity suggested an approximately linear relationship
                      (Pnonlinearity = .94). The inverse association was
                      particularly strong for human epidermal growth factor
                      receptor 2-enriched breast cancer (HR, 0.57 $[95\%$ CI, 0.39
                      to 0.84]; Phet = .07). Associations did not vary
                      significantly across strata of breast cancer risk factors,
                      including subgroups of adiposity.This large, pooled analysis
                      of cohort studies adds to evidence that engagement in higher
                      levels of leisure-time physical activity may lead to reduced
                      premenopausal breast cancer risk.},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38079601},
      doi          = {10.1200/JCO.23.01101},
      url          = {https://inrepo02.dkfz.de/record/286099},
}