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@ARTICLE{Bhatla:286103,
      author       = {N. Bhatla and R. Muwonge and S. G. Malvi and S. Joshi and
                      U. R. R. Poli and E. Lucas and P. O. Esmy and Y. Verma and
                      A. Shah and E. Zomawia and S. Pimple and K. Jayant and S.
                      Hingmire and A. Chiwate and S. Vashist and G. Mishra and R.
                      Jadhav and M. Siddiqi and D. Anantharaman and G. Panicker
                      and J. Butt$^*$ and S. Sankaran and T. P. R. A. Kannan and
                      R. Varghese and P. Kartha and M. R. Pillai and T.
                      Waterboer$^*$ and M. Müller$^*$ and P. Sehr$^*$ and E. R.
                      Unger and R. Sankaranarayanan and P. Basu},
      title        = {{I}mpact of age at vaccination and cervical {HPV} infection
                      status on binding and neutralizing antibody titers at 10
                      years after receiving single or higher doses of quadrivalent
                      {HPV} vaccine.},
      journal      = {Human vaccines $\&$ immunotherapeutics},
      volume       = {19},
      number       = {3},
      issn         = {2164-5515},
      address      = {Austin, Tex.},
      publisher    = {Landes Bioscience},
      reportid     = {DKFZ-2023-02679},
      pages        = {2289242},
      year         = {2023},
      abstract     = {Long-term follow-up of a cohort of unmarried girls who
                      received one, two, or three doses of quadrivalent HPV
                      vaccine, between 10 and 18 years of age, in an Indian
                      multi-centric study allowed us to compare antibody responses
                      between the younger and older age cohorts at 10-years
                      post-vaccination, and study the impact of initiation of
                      sexual activity and cervical HPV infections on antibody
                      levels. Among the younger (10-14 years) recipients of a
                      single dose, $97.7\%$ and $98.2\%$ had detectable binding
                      antibody titers against HPV 16 and HPV 18 respectively at
                      ten years post-vaccination. The proportions among those
                      receiving a single dose at age 15-18 years were $92.3\%$ and
                      $94.2\%$ against HPV 16 and HPV 18 respectively. Mean HPV 16
                      binding antibody titers were 2.1 folds $(95\%CI$ 1.4 to 3.3)
                      higher in those vaccinated at ages 10-14 years, and 1.9
                      folds $(95\%CI$ 1.2 to 3.0) higher in those vaccinated at
                      15-18 years compared to mean titers seen in the unvaccinated
                      women. Compared to previous timepoints of 36 or 48 months,
                      binding antibodies against HPV 16 and neutralizing
                      antibodies against both HPV 16 and HPV 18 were significantly
                      higher at 10 years. This rise was more pronounced in
                      participants vaccinated at 15-18 years. No association of
                      marital status or cervical HPV infections was observed with
                      the rise in titer. Durability of antibody response in single
                      dose recipients correlated well with the high efficacy of a
                      single dose against persistent HPV 16/18 infections
                      irrespective of age at vaccination, as we reported earlier.},
      keywords     = {HPV (Other) / Human papillomavirus (Other) / age-stratified
                      (Other) / binding antibody (Other) / neutralizing antibody
                      (Other) / single dose (Other) / vaccine (Other)},
      cin          = {F020 / W040},
      ddc          = {610},
      cid          = {I:(DE-He78)F020-20160331 / I:(DE-He78)W040-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38078840},
      doi          = {10.1080/21645515.2023.2289242},
      url          = {https://inrepo02.dkfz.de/record/286103},
}