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@ARTICLE{Heiss:286213,
      author       = {R. Heiss and M.-A. Weber and E. L. Balbach and M. Hinsen
                      and F. Geissler and A. M. Nagel$^*$ and M. E. Ladd$^*$ and
                      A. Arkudas and R. E. Horch and C. Gall and M. Uder and F. W.
                      Roemer},
      title        = {{V}ariation in cartilage {T}2 and {T}2* mapping of the
                      wrist: a comparison between 3- and 7-{T} {MRI}.},
      journal      = {European radiology experimental},
      volume       = {7},
      number       = {1},
      issn         = {2509-9280},
      address      = {[Cham]},
      publisher    = {Springer International Publishing},
      reportid     = {DKFZ-2023-02717},
      pages        = {80},
      year         = {2023},
      abstract     = {To analyze regional variations in T2 and T2* relaxation
                      times in wrist joint cartilage and the triangular
                      fibrocartilage complex (TFCC) at 3 and 7 T and to compare
                      values between field strengths.Twenty-five healthy controls
                      and 25 patients with chronic wrist pain were examined at 3
                      and 7 T on the same day using T2- and T2*-weighted
                      sequences. Six different regions of interest (ROIs) were
                      evaluated for cartilage and 3 ROIs were evaluated at the
                      TFCC based on manual segmentation. Paired t-tests were used
                      to compare T2 and T2* values between field strengths and
                      between different ROIs. Spearman's rank correlation was
                      calculated to assess correlations between T2 and T2* time
                      values at 3 and 7 T.T2 and T2* time values of the cartilage
                      differed significantly between 3 and 7 T for all ROIs (p ≤
                      0.045), with one exception: at the distal lunate, no
                      significant differences in T2 values were observed between
                      field strengths. T2* values differed significantly between 3
                      and 7 T for all ROIs of the TFCC (p ≤ 0.001). Spearman's
                      rank correlation between 3 and 7 T ranged from 0.03 to 0.62
                      for T2 values and from 0.01 to 0.48 for T2* values. T2 and
                      T2* values for cartilage varied across anatomic locations in
                      healthy controls at both 3 and 7 T.Quantitative results of
                      T2 and T2* mapping at the wrist differ between field
                      strengths, with poor correlation between 3 and 7 T. Local
                      variations in cartilage T2 and T2* values are observed in
                      healthy individuals.T2 and T2* mapping are feasible for
                      compositional imaging of the TFCC and the cartilage at the
                      wrist at both 3 and 7 T, but the clinical interpretation
                      remains challenging due to differences between field
                      strengths and variations between anatomic locations.•Field
                      strength and anatomic locations influence T2 and T2* values
                      at the wrist. •T2 and T2* values have a poor correlation
                      between 3 and 7 T. •Local reference values are needed for
                      each anatomic location for reliable interpretation.},
      keywords     = {Cartilage (articular) (Other) / Image processing
                      (computer-assisted) (Other) / Magnetic resonance imaging
                      (Other) / Triangular fibrocartilage (Other) / Wrist joint
                      (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38093075},
      doi          = {10.1186/s41747-023-00394-1},
      url          = {https://inrepo02.dkfz.de/record/286213},
}