TY  - JOUR
AU  - Stern, Mariana C
AU  - Sanchez Mendez, Joel
AU  - Kim, Andre E
AU  - Obón-Santacana, Mireia
AU  - Moratalla-Navarro, Ferran
AU  - Martín, Vicente
AU  - Moreno, Victor
AU  - Lin, Yi
AU  - Bien, Stephanie A
AU  - Qu, Conghui
AU  - Su, Yu-Ru
AU  - White, Emily
AU  - Harrison, Tabitha A
AU  - Huyghe, Jeroen R
AU  - Tangen, Catherine M
AU  - Newcomb, Polly A
AU  - Phipps, Amanda I
AU  - Thomas, Claire E
AU  - Kawaguchi, Eric S
AU  - Lewinger, Juan Pablo
AU  - Morrison, John L
AU  - Conti, David V
AU  - Wang, Jun
AU  - Thomas, Duncan C
AU  - Platz, Elizabeth A
AU  - Visvanathan, Kala
AU  - Keku, Temitope O
AU  - Newton, Christina C
AU  - Um, Caroline Y
AU  - Kundaje, Anshul
AU  - Shcherbina, Anna
AU  - Murphy, Neil
AU  - Gunter, Marc J
AU  - Dimou, Niki
AU  - Papadimitriou, Nikos
AU  - Bézieau, Stéphane
AU  - van Duijnhoven, Fränzel Jb
AU  - Männistö, Satu
AU  - Rennert, Gad
AU  - Wolk, Alicja
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Chang-Claude, Jenny
AU  - Tian, Yu
AU  - Le Marchand, Loïc
AU  - Cotterchio, Michelle
AU  - Tsilidis, Konstantinos K
AU  - Bishop, D Timothy Timothy
AU  - Melaku, Yohannes Adama
AU  - Lynch, Brigid M
AU  - Buchanan, Daniel D
AU  - Ulrich, Cornelia M
AU  - Ose, Jennifer
AU  - Peoples, Anita R
AU  - Pellatt, Andrew J
AU  - Li, Li
AU  - Devall, Matthew Am
AU  - Campbell, Peter T
AU  - Albanes, Demetrius
AU  - Weinstein, Stephanie J
AU  - Berndt, Sonja I
AU  - Gruber, Stephen B
AU  - Ruiz-Narvaez, Edward
AU  - Song, Mingyang
AU  - Joshi, Amit D
AU  - Drew, David A
AU  - Petrick, Jessica L
AU  - Chan, Andrew T
AU  - Giannakis, Marios
AU  - Peters, Ulrike
AU  - Hsu, Li
AU  - Gauderman, W James
TI  - Genome-wide gene-environment interaction analyses to understand the relationship between red meat and processed meat intake and colorectal cancer risk.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 33
IS  - 3
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2023-02778
SP  - 400-410
PY  - 2024
N1  - 2024 Mar 1;33(3):400-410
AB  - High red meat and/or processed meat consumption are established colorectal cancer (CRC) risk factors. We conducted a genome-wide gene-environment (GxE) interaction analysis to identify genetic variants that may modify these associations.A pooled sample of 29,842 CRC cases and 39,635 controls of European ancestry from 27 studies were included. Quantiles for red meat and processed meat intake were constructed from harmonized questionnaire data. Genotyping arrays were imputed to the Haplotype Reference Consortium. Two-step EDGE and joint tests of GxE interaction were utilized in our genome-wide scan.Meta-analyses confirmed positive associations between increased consumption of red meat and processed meat with CRC risk (per quartile red meat OR = 1.30; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:38112776
DO  - DOI:10.1158/1055-9965.EPI-23-0717
UR  - https://inrepo02.dkfz.de/record/286375
ER  -