TY  - JOUR
AU  - Cornish, Naomi
AU  - Haycock, Philip
AU  - Brenner, Hermann
AU  - Figueiredo, Jane C
AU  - Galesloot, Tessel E
AU  - Grant, Robert C
AU  - Johansson, Mattias
AU  - Mariosa, Daniela
AU  - McKay, James
AU  - Pai, Rish
AU  - Pellatt, Andrew J
AU  - Samadder, N Jewel
AU  - Shi, Jianxin
AU  - Thibord, Florian
AU  - Trégouët, David-Alexandre
AU  - Voegele, Catherine
AU  - Thirlwell, Chrissie
AU  - Mumford, Andrew
AU  - Langdon, Ryan
TI  - Causal relationships between risk of venous thromboembolism and 18 cancers: a bidirectional Mendelian randomization analysis.
JO  - International journal of epidemiology
VL  - 53
IS  - 1
SN  - 0300-5771
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2023-02780
SP  - dyad170
PY  - 2024
N1  - 2024 Feb 1;53(1):dyad170
AB  - People with cancer experience high rates of venous thromboembolism (VTE). Risk of subsequent cancer is also increased in people experiencing their first VTE. The causal mechanisms underlying this association are not completely understood, and it is unknown whether VTE is itself a risk factor for cancer.We used data from large genome-wide association study meta-analyses to perform bidirectional Mendelian randomization analyses to estimate causal associations between genetic liability to VTE and risk of 18 different cancers.We found no conclusive evidence that genetic liability to VTE was causally associated with an increased incidence of cancer, or vice versa. We observed an association between liability to VTE and pancreatic cancer risk [odds ratio for pancreatic cancer: 1.23 (95
KW  - Mendelian randomization (Other)
KW  - deep vein thrombosis (Other)
KW  - genetic epidemiology (Other)
KW  - malignancy (Other)
KW  - pulmonary embolus (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38124529
DO  - DOI:10.1093/ije/dyad170
UR  - https://inrepo02.dkfz.de/record/286377
ER  -