TY  - JOUR
AU  - Bull, Caroline
AU  - Hazelwood, Emma
AU  - Bell, Joshua A
AU  - Tan, Vanessa
AU  - Constantinescu, Andrei-Emil
AU  - Borges, Carolina
AU  - Legge, Danny
AU  - Burrows, Kimberley
AU  - Huyghe, Jeroen R
AU  - Brenner, Hermann
AU  - Castellvi-Bel, Sergi
AU  - Chan, Andrew T
AU  - Kweon, Sun-Seog
AU  - Le Marchand, Loic
AU  - Li, Li
AU  - Cheng, Iona
AU  - Pai, Rish K
AU  - Figueiredo, Jane C
AU  - Murphy, Neil
AU  - Gunter, Marc J
AU  - Timpson, Nicholas J
AU  - Vincent, Emma E
TI  - Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
JO  - eLife
VL  - 12
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - DKFZ-2023-02786
SP  - RP87894
PY  - 2023
AB  - Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival.To investigate whether changes in circulating metabolites characterize the early stages of colorectal cancer (CRC) development, we examined the associations between a genetic risk score (GRS) associated with CRC liability (72 single-nucleotide polymorphisms) and 231 circulating metabolites measured by nuclear magnetic resonance spectroscopy in the Avon Longitudinal Study of Parents and Children (N = 6221). Linear regression models were applied to examine the associations between genetic liability to CRC and circulating metabolites measured in the same individuals at age 8 y, 16 y, 18 y, and 25 y.The GRS for CRC was associated with up to 28
KW  - Mendelian randomization (Other)
KW  - cancer biology (Other)
KW  - colorectal cancer (Other)
KW  - epidemiology (Other)
KW  - global health (Other)
KW  - human (Other)
KW  - metabolomics (Other)
KW  - obesity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38127078
DO  - DOI:10.7554/eLife.87894
UR  - https://inrepo02.dkfz.de/record/286383
ER  -