000286387 001__ 286387
000286387 005__ 20240229155126.0
000286387 0247_ $$2doi$$a10.1073/pnas.2311460120
000286387 0247_ $$2pmid$$apmid:38127986
000286387 0247_ $$2ISSN$$a0027-8424
000286387 0247_ $$2ISSN$$a1091-6490
000286387 0247_ $$2altmetric$$aaltmetric:157697814
000286387 037__ $$aDKFZ-2023-02790
000286387 041__ $$aEnglish
000286387 082__ $$a500
000286387 1001_ $$aHassin, Ori$$b0
000286387 245__ $$ap53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells.
000286387 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2023
000286387 3367_ $$2DRIVER$$aarticle
000286387 3367_ $$2DataCite$$aOutput Types/Journal article
000286387 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1703256998_4707
000286387 3367_ $$2BibTeX$$aARTICLE
000286387 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000286387 3367_ $$00$$2EndNote$$aJournal Article
000286387 520__ $$aThe TP53 gene is mutated in approximately 30% of all breast cancer cases. Adipocytes and preadipocytes, which constitute a substantial fraction of the stroma of normal mammary tissue and breast tumors, undergo transcriptional, metabolic, and phenotypic reprogramming during breast cancer development and play an important role in tumor progression. We report here that p53 loss in breast cancer cells facilitates the reprogramming of preadipocytes, inducing them to acquire a unique transcriptional and metabolic program that combines impaired adipocytic differentiation with augmented cytokine expression. This, in turn, promotes the establishment of an inflammatory tumor microenvironment, including increased abundance of Ly6C+ and Ly6G+ myeloid cells and elevated expression of the immune checkpoint ligand PD-L1. We also describe a potential gain-of-function effect of common p53 missense mutations on the inflammatory reprogramming of preadipocytes. Altogether, our study implicates p53 deregulation in breast cancer cells as a driver of tumor-supportive adipose tissue reprogramming, expanding the network of non-cell autonomous mechanisms whereby p53 dysfunction may promote cancer. Further elucidation of the interplay between p53 and adipocytes within the tumor microenvironment may suggest effective therapeutic targets for the treatment of breast cancer patients.
000286387 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
000286387 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000286387 650_7 $$2Other$$aadipocytes
000286387 650_7 $$2Other$$abreast cancer
000286387 650_7 $$2Other$$ap53
000286387 650_7 $$2Other$$apreadipocytes
000286387 7001_ $$aSernik, Miriam$$b1
000286387 7001_ $$00009-0000-8176-3509$$aSeligman, Adi$$b2
000286387 7001_ $$0P:(DE-He78)38900a0e1ae96a725db546cb7b909adb$$aVogel, Felix Christian Eduard$$b3$$udkfz
000286387 7001_ $$aWellenstein, Max D$$b4
000286387 7001_ $$aSmollich, Joachim$$b5
000286387 7001_ $$aHalperin, Coral$$b6
000286387 7001_ $$aPirona, Anna Chiara$$b7
000286387 7001_ $$aToledano, Liron Nomi$$b8
000286387 7001_ $$0P:(DE-HGF)0$$aCaballero, Carolina Dehesa$$b9
000286387 7001_ $$0P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d$$aSchlicker, Lisa$$b10$$udkfz
000286387 7001_ $$aSalame, Tomer-Meir$$b11
000286387 7001_ $$aSarusi Portuguez, Avital$$b12
000286387 7001_ $$aAylon, Yael$$b13
000286387 7001_ $$00000-0002-4570-121X$$aScherz-Shouval, Ruth$$b14
000286387 7001_ $$aGeiger, Tamar$$b15
000286387 7001_ $$ade Visser, Karin E$$b16
000286387 7001_ $$0P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aSchulze, Almut$$b17$$udkfz
000286387 7001_ $$00000-0003-4311-7172$$aOren, Moshe$$b18
000286387 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.2311460120$$gVol. 120, no. 52, p. e2311460120$$n52$$pe2311460120$$tProceedings of the National Academy of Sciences of the United States of America$$v120$$x0027-8424$$y2023
000286387 909CO $$ooai:inrepo02.dkfz.de:286387$$pVDB
000286387 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)38900a0e1ae96a725db546cb7b909adb$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000286387 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000286387 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000286387 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aDeutsches Krebsforschungszentrum$$b17$$kDKFZ
000286387 9131_ $$0G:(DE-HGF)POF4-311$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vZellbiologie und Tumorbiologie$$x0
000286387 9141_ $$y2023
000286387 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2023-08-26$$wger
000286387 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bP NATL ACAD SCI USA : 2022$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-26
000286387 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bP NATL ACAD SCI USA : 2022$$d2023-08-26
000286387 9201_ $$0I:(DE-He78)A410-20160331$$kA410$$lMetabolismus und Microenvironment$$x0
000286387 980__ $$ajournal
000286387 980__ $$aVDB
000286387 980__ $$aI:(DE-He78)A410-20160331
000286387 980__ $$aUNRESTRICTED