%0 Journal Article
%A Kommoss, Katharina
%A Bieler, Tabea
%A Ringen, Julia
%A Lehmann, Annika
%A Mihalceanu, Silvia
%A Hobohm, Lukas
%A Keller, Karsten
%A Brand, Anna
%A Fischer, Berenice
%A Kramer, Daniela
%A Wild, Johannes
%A Waisman, Ari
%A Enk, Alexander
%A Schäkel, Knut
%A Heikenwälder, Mathias
%A Karbach, Susanne
%T A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease.
%J Journal of molecular medicine
%V 102
%N 2
%@ 0023-2173
%C New York, NY
%I Springer
%M DKFZ-2023-02791
%P 247-255
%D 2024
%Z #EA:F180#LA:F180# / 2024 Feb;102(2):247-255
%X Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in psoriasis patients and five murine models of psoriasis-like skin disease based on topical imiquimod application and overexpression of IL-17A under different promotors. We performed a single-center prospective observational study in a German population, investigating psoriasis patients prior to, 4 weeks, and 16 weeks post begin of systemic anti-inflammatory therapy. Psoriasis area and severity index (PASI), blood count, and C-reactive protein (CRP) levels were attained at each timepoint. Additionally, five murine models of psoriasis-like skin disease involving five distinct experimental procedures differing in time of disease-onset and severity were investigated regarding PLR and NLR. Of 43 recruited psoriasis patients, 34 patients were followed up to 16 weeks. The cohort was 69.77
%K Interleukin-17A (Other)
%K Neutrophil-to-lymphocyte ratio (Other)
%K Platelet-to-lymphocyte ratio (Other)
%K Psoriasis (Other)
%K Psoriasis-comorbidities (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38127137
%R 10.1007/s00109-023-02406-4
%U https://inrepo02.dkfz.de/record/286388