TY  - JOUR
AU  - Kommoss, Katharina
AU  - Bieler, Tabea
AU  - Ringen, Julia
AU  - Lehmann, Annika
AU  - Mihalceanu, Silvia
AU  - Hobohm, Lukas
AU  - Keller, Karsten
AU  - Brand, Anna
AU  - Fischer, Berenice
AU  - Kramer, Daniela
AU  - Wild, Johannes
AU  - Waisman, Ari
AU  - Enk, Alexander
AU  - Schäkel, Knut
AU  - Heikenwälder, Mathias
AU  - Karbach, Susanne
TI  - A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease.
JO  - Journal of molecular medicine
VL  - 102
IS  - 2
SN  - 0023-2173
CY  - New York, NY
PB  - Springer
M1  - DKFZ-2023-02791
SP  - 247-255
PY  - 2024
N1  - #EA:F180#LA:F180# / 2024 Feb;102(2):247-255
AB  - Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in psoriasis patients and five murine models of psoriasis-like skin disease based on topical imiquimod application and overexpression of IL-17A under different promotors. We performed a single-center prospective observational study in a German population, investigating psoriasis patients prior to, 4 weeks, and 16 weeks post begin of systemic anti-inflammatory therapy. Psoriasis area and severity index (PASI), blood count, and C-reactive protein (CRP) levels were attained at each timepoint. Additionally, five murine models of psoriasis-like skin disease involving five distinct experimental procedures differing in time of disease-onset and severity were investigated regarding PLR and NLR. Of 43 recruited psoriasis patients, 34 patients were followed up to 16 weeks. The cohort was 69.77
KW  - Interleukin-17A (Other)
KW  - Neutrophil-to-lymphocyte ratio (Other)
KW  - Platelet-to-lymphocyte ratio (Other)
KW  - Psoriasis (Other)
KW  - Psoriasis-comorbidities (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38127137
DO  - DOI:10.1007/s00109-023-02406-4
UR  - https://inrepo02.dkfz.de/record/286388
ER  -