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@ARTICLE{Kommoss:286388,
      author       = {K. Kommoss$^*$ and T. Bieler$^*$ and J. Ringen and A.
                      Lehmann and S. Mihalceanu and L. Hobohm and K. Keller and A.
                      Brand and B. Fischer and D. Kramer and J. Wild and A.
                      Waisman and A. Enk and K. Schäkel and M. Heikenwälder$^*$
                      and S. Karbach},
      title        = {{A} simple tool for evaluation of inflammation in
                      psoriasis: {N}eutrophil-to-lymphocyte and
                      platelet-to-lymphocyte ratio as markers in psoriasis
                      patients and related murine models of psoriasis-like skin
                      disease.},
      journal      = {Journal of molecular medicine},
      volume       = {102},
      number       = {2},
      issn         = {0023-2173},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-02791},
      pages        = {247-255},
      year         = {2024},
      note         = {#EA:F180#LA:F180# / 2024 Feb;102(2):247-255},
      abstract     = {Objective parameters to quantify psoriatic inflammation are
                      needed for interdisciplinary patient care, as well as
                      preclinical experimental models. This study evaluates
                      neutrophil-to-lymphocyte ratio (NLR) and
                      platelet-to-lymphocyte ratio (PLR) in psoriasis patients and
                      five murine models of psoriasis-like skin disease based on
                      topical imiquimod application and overexpression of IL-17A
                      under different promotors. We performed a single-center
                      prospective observational study in a German population,
                      investigating psoriasis patients prior to, 4 weeks, and 16
                      weeks post begin of systemic anti-inflammatory therapy.
                      Psoriasis area and severity index (PASI), blood count, and
                      C-reactive protein (CRP) levels were attained at each
                      timepoint. Additionally, five murine models of
                      psoriasis-like skin disease involving five distinct
                      experimental procedures differing in time of disease-onset
                      and severity were investigated regarding PLR and NLR. Of 43
                      recruited psoriasis patients, 34 patients were followed up
                      to 16 weeks. The cohort was $69.77\%$ male, showing a median
                      age of 32.0 years (range 19.0-67.0; IQR 26). The median PASI
                      decreased from 16.35 (8.0-50.0; 10.20) to 1.6 (0-10.3; 2.56)
                      after 16 weeks of systemic therapy. Spearman's correlation
                      showed statistically significant positive correlation for
                      NLR with PASI (rs = 0.27, p = 0.006), however not for PLR.
                      NLR, but not PLR, was significantly associated with PASI in
                      a multiple linear regression analysis including age, sex,
                      psoriasis arthritis, and smoking. In the murine models of
                      psoriasis-like skin disease, both NLR and PLR were
                      significantly increased in the acute-severe models compared
                      to controls (p < 0.001, p = 0.005, and p = 0.02,
                      respectively), demonstrating gradually less increased values
                      from severe-acute to mild-late-onset psoriatic phenotype.
                      NLR was significantly associated with PASI in psoriatic
                      patients as well as psoriatic phenotype in different murine
                      psoriasis models. Our data warrants investigation of NLR in
                      psoriasis patients and preclinical psoriasis models as an
                      objective biomarker of psoriatic skin inflammation. KEY
                      MESSAGES : NLR, but not PLR, showed a statistically
                      significant positive correlation with Psoriasis Area and
                      Severity Index (PASI) in our human psoriasis cohort. Both
                      NLR and PLR were significantly increased in murine psoriasis
                      models compared to matched controls, with gradually less
                      increased values from severe-acute to mild-late-onset
                      psoriatic phenotype. NLR may represent an easily available,
                      cheap, and objective parameter to monitor psoriatic
                      inflammation in both clinical patient routine, as well as
                      preclinical experimental murine models.},
      keywords     = {Interleukin-17A (Other) / Neutrophil-to-lymphocyte ratio
                      (Other) / Platelet-to-lymphocyte ratio (Other) / Psoriasis
                      (Other) / Psoriasis-comorbidities (Other)},
      cin          = {F180},
      ddc          = {610},
      cid          = {I:(DE-He78)F180-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38127137},
      doi          = {10.1007/s00109-023-02406-4},
      url          = {https://inrepo02.dkfz.de/record/286388},
}