guest ::
| Home > Publications database > Detection of serum biomarkers of HPV-16 driven oropharynx and oral cavity cancer in Brazil. > print |
| Home > Publications database > Detection of serum biomarkers of HPV-16 driven oropharynx and oral cavity cancer in Brazil. > print |
| 001 | 286587 | ||
| 005 | 20240229155126.0 | ||
| 024 | 7 | _ | |a 10.1016/j.oraloncology.2023.106676 |2 doi |
| 024 | 7 | _ | |a pmid:38150987 |2 pmid |
| 024 | 7 | _ | |a 0964-1955 |2 ISSN |
| 024 | 7 | _ | |a 1368-8375 |2 ISSN |
| 024 | 7 | _ | |a 1878-6766 |2 ISSN |
| 024 | 7 | _ | |a 1879-0593 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2023-02804 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Sichero, Laura |b 0 |
| 245 | _ | _ | |a Detection of serum biomarkers of HPV-16 driven oropharynx and oral cavity cancer in Brazil. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2024 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1703840319_2100 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Volume 149, February 2024, 106676 |
| 520 | _ | _ | |a HPV-16 driven oropharynx/oral cavity squamous cell carcinomas prevalence varies globally. We evaluated the presence of HPV-16 ctDNA and HPV-16 E6 antibodies in samples obtained from participants treated at the Instituto do Cancer do Estado de Sao Paulo, ICESP, and from whom tumoral HPV DNA, HPV-16 E6*I mRNA, and p16INK4a status was also accessed.HPV was genotyped by PCR-hybridization. All HPV DNA positive and ∼10 % HPV DNA negative cases underwent p16INK4a immunohistochemistry and E6*I RNA testing using a multiplex bead based protocol. HPV-16 ctDNA and anti-E6 antibodies were assessed by ddPCR (digital droplet PCR) and multiplex serology, respectively.The prevalence of HPV-16 in oropharynx carcinoma (OPC) cases was low (8.7 %) when considering solely HPV-16 DNA detection, and even lower (5.2 %) when taken into consideration the concomitant detection of HPV-16 E6*I RNA and/or p16INK4 (HPV-16 attributable fraction - AF). None of the oral cavity cancer (OCC) cases were detected with HPV-16 DNA. HPV-16 ctDNA was more commonly detected than HPV-16 E6 antibodies (29.8 % versus 10.6 %). Both serum biomarkers attained 100 % sensitivity of detecting HPV-16 AF OPC, however the specificity of the HPV-16 anti-E6 biomarker was higher compared to ctDNA (93.2 % versus 75.0 %). Finally, when both HPV-16 ctDNA and anti-E6 biomarkers were considered together, the sensitivity and specificity for HPV-16 OPC detection was 100 % and about 70 %, respectively, independently of analyzing HPV-16 DNA positive or HPV-16 AF tumors.Our findings corroborate that serum biomarkers are highly sensitive and specific biomarkers for detection of HPV-associated OPC. |
| 536 | _ | _ | |a 316 - Infektionen, Entzündung und Krebs (POF4-316) |0 G:(DE-HGF)POF4-316 |c POF4-316 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a Antibodies |2 Other |
| 650 | _ | 7 | |a HPV ctDNA |2 Other |
| 650 | _ | 7 | |a Head and neck cancer |2 Other |
| 650 | _ | 7 | |a Human papillomavirus |2 Other |
| 650 | _ | 7 | |a Serum biomarkers |2 Other |
| 700 | 1 | _ | |a Gonçalves, Milena Giulia |b 1 |
| 700 | 1 | _ | |a Bettoni, Fabiana |b 2 |
| 700 | 1 | _ | |a Coser, Elisangela Monteiro |b 3 |
| 700 | 1 | _ | |a Mota, Giana |b 4 |
| 700 | 1 | _ | |a Nunes, Rafaella A L |b 5 |
| 700 | 1 | _ | |a Mercante, Ana Maria da Cunha |b 6 |
| 700 | 1 | _ | |a Natalino, Renato |b 7 |
| 700 | 1 | _ | |a Uno, Miyuki |b 8 |
| 700 | 1 | _ | |a Ferreira Alves, Maria José |b 9 |
| 700 | 1 | _ | |a Matos, Leandro Luongo |b 10 |
| 700 | 1 | _ | |a Kowalski, Luiz Paulo |b 11 |
| 700 | 1 | _ | |a Kulcsar, Marco Aurélio Vamondes |b 12 |
| 700 | 1 | _ | |a de Alvarenga, Gustavo Fernandes |b 13 |
| 700 | 1 | _ | |a Höfler, Daniela |0 P:(DE-He78)3b05a05c74fcfafec06747c40ac929c0 |b 14 |u dkfz |
| 700 | 1 | _ | |a Schroeder, Lea |0 P:(DE-He78)b12aaacaa142dabed85c6d84d00bf0fb |b 15 |u dkfz |
| 700 | 1 | _ | |a Waterboer, Tim |0 P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30 |b 16 |u dkfz |
| 700 | 1 | _ | |a Tommasino, Massimo |b 17 |
| 700 | 1 | _ | |a Villa, Luisa Lina |b 18 |
| 773 | _ | _ | |a 10.1016/j.oraloncology.2023.106676 |g Vol. 149, p. 106676 - |0 PERI:(DE-600)2011971-9 |p 106676 |t Oral oncology |v 149 |y 2024 |x 0964-1955 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:286587 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)3b05a05c74fcfafec06747c40ac929c0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)b12aaacaa142dabed85c6d84d00bf0fb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-316 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Infektionen, Entzündung und Krebs |x 0 |
| 914 | 1 | _ | |y 2023 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-10-22 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ORAL ONCOL : 2022 |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-10-22 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-10-22 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2023-10-22 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2023-10-22 |
| 920 | 1 | _ | |0 I:(DE-He78)F020-20160331 |k F020 |l Infektionen und Krebs-Epidemiologie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)F020-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|