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@ARTICLE{Li:286610,
      author       = {C. Li and L. Tan and X. Xu$^*$ and S. Chen and C. Huang},
      title        = {{C}hanges of {O}ptic {D}isc and {M}acular {V}essel
                      {P}erfusion {D}ensity in {P}rimary {A}ngle {C}losure
                      {G}laucoma: {A} {Q}uantitative {S}tudy {U}sing {O}ptical
                      {C}oherence {T}omography {A}ngiograph.},
      journal      = {Ophthalmic research},
      volume       = {66},
      number       = {1},
      issn         = {0030-3747},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DKFZ-2023-02822},
      pages        = {1245 - 1253},
      year         = {2023},
      abstract     = {This study aims to investigate the changes of retinal
                      vascular system in primary angle closure glaucoma (PACG) and
                      acute primary angle closure (APAC) by optical coherence
                      tomography (OCT) angiograph (OCTA) and to evaluate the
                      diagnostic ability of changes of vessel density (VD) in
                      different sectors and layers of optic disc and macular area
                      in APAC and PACG.In this cross-sectional, observational
                      study, 21 APAC patients (22 eyes) and 21 PACG patients (27
                      eyes) along with 17 healthy people were enrolled from August
                      2018 to March 2019. Optic disc region and macular region
                      were imaged using swept-source OCTA system. VD of the
                      macular region was quantified by Image J (1.52a, USA) and
                      Matlab 2018a. The circumpapillary retinal nerve fiber layer
                      (cpRNFL) thickness and ganglion cell complex thickness were
                      obtained by spectral-domain OCT.Compared with the healthy
                      group, the cpRNFL thickness in superior sector was thicker
                      in the APAC group, and this area had the most diffuse
                      microvascular dropout as well. The difference in the macular
                      superficial capillary plexus (SCP) VD between APAC and the
                      control group was not statistically significant. The area
                      under the ROC curves (AUC) of the total optic disc VD in the
                      radial peripapillary capillary (RPC) layer was higher than
                      the AUC of the papillary VD in the optic nerve head (ONH)
                      layer. Compared to the control group, the total optic disc
                      VD, peripapillary VD, and each quadrant of peripapillary VD
                      were decreased in PACG (p < 0.01). In PACG macular region,
                      SCP VD, and deep capillary plexus (DCP) VD, parafovea VD
                      (except temporal sectors) decreased (p < 0.01). The PACG
                      eyes had a greater decrease percentage of VD in total ONH
                      than total macula. The diagnostic value of the VD in the ONH
                      layer and the RPC layer was similar. The diagnostic value of
                      the SCP VD in the macula was greater than the DCP VD in the
                      macula. The AUC was no significant difference between cpRNFL
                      thickness and the total optic disc VD AUC.Elevated
                      intraocular pressure preferentially affects vascular
                      perfusion in the optic disc region more than the macular
                      region in APAC and PACG. In the APAC eyes, there was a
                      perfusion defect in the optic disc region and an increase in
                      RNFL thickness. In this study, the OCTA vascular parameters
                      have similar performance to the OCT structural parameters
                      for glaucoma diagnosis in PACG.},
      keywords     = {Humans / Optic Disk: blood supply / Tomography, Optical
                      Coherence: methods / Glaucoma, Angle-Closure: diagnosis /
                      Glaucoma, Open-Angle: diagnosis / Cross-Sectional Studies /
                      Retinal Vessels / Intraocular Pressure / Glaucoma: diagnosis
                      / Perfusion / Fluorescein Angiography: methods / Ganglion
                      cell complex (Other) / Optical coherence tomography
                      angiography (Other) / Primary angle closure glaucoma (Other)
                      / Retinal nerve fiber layer (Other) / Vessel density
                      (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37647877},
      pmc          = {pmc:PMC10614527},
      doi          = {10.1159/000533874},
      url          = {https://inrepo02.dkfz.de/record/286610},
}