%0 Journal Article
%A Papadimitriou, Nikos
%A Kazmi, Nabila
%A Dimou, Niki
%A Tsilidis, Konstantinos K
%A Martin, Richard M
%A Lewis, Sarah J
%A Lynch, Brigid M
%A Hoffmeister, Michael
%A Kweon, Sun-Seog
%A Li, Li
%A Milne, Roger L
%A Sakoda, Lori C
%A Schoen, Robert E
%A Phipps, Amanda I
%A Figueiredo, Jane C
%A Peters, Ulrike
%A Dixon-Suen, Suzanne C
%A Gunter, Marc J
%A Murphy, Neil
%T Leisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis.
%J Cancer medicine
%V 13
%N 1
%@ 2045-7634
%C Hoboken, NJ
%I Wiley
%M DKFZ-2023-02823
%P e6732
%D 2024
%Z 2024 Jan;13(1):e6732
%X Sedentary behaviours have been associated with increased risks of some common cancers in epidemiological studies; however, it is unclear if these associations are causal.We used univariable and multivariable two-sample Mendelian randomisation (MR) to examine potential causal relationships between sedentary behaviours and risks of breast, colorectal and prostate cancer. Genetic variants associated with self-reported leisure television watching and computer use were identified from a recent genome-wide association study (GWAS). Data related to cancer risk were obtained from cancer GWAS consortia. A series of sensitivity analyses were applied to examine the robustness of the results to the presence of confounding.A 1-standard deviation (SD: 1.5 h/day) increment in hours of television watching increased risk of breast cancer (OR per 1-SD: 1.15, 95
%K Mendelian randomisation (Other)
%K breast cancer (Other)
%K colorectal cancer (Other)
%K prostate cancer (Other)
%K sedentary activities (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38155458
%R 10.1002/cam4.6732
%U https://inrepo02.dkfz.de/record/286611