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000286611 1001_ $$00000-0001-8294-7262$$aPapadimitriou, Nikos$$b0
000286611 245__ $$aLeisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis.
000286611 260__ $$aHoboken, NJ$$bWiley$$c2024
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000286611 520__ $$aSedentary behaviours have been associated with increased risks of some common cancers in epidemiological studies; however, it is unclear if these associations are causal.We used univariable and multivariable two-sample Mendelian randomisation (MR) to examine potential causal relationships between sedentary behaviours and risks of breast, colorectal and prostate cancer. Genetic variants associated with self-reported leisure television watching and computer use were identified from a recent genome-wide association study (GWAS). Data related to cancer risk were obtained from cancer GWAS consortia. A series of sensitivity analyses were applied to examine the robustness of the results to the presence of confounding.A 1-standard deviation (SD: 1.5 h/day) increment in hours of television watching increased risk of breast cancer (OR per 1-SD: 1.15, 95% confidence interval [CI]: 1.05-1.26) and colorectal cancer (OR per 1-SD: 1.32, 95% CI: 1.16-1.49) while there was little evidence of an association for prostate cancer risk (OR per 1-SD: 0.94, 95% CI: 0.84-1.06). After adjusting for years of education, the effect estimates for television watching were attenuated (breast cancer, OR per 1-SD: 1.08, 95% CI: 0.92-1.27; colorectal cancer, OR per 1-SD: 1.08, 95% CI: 0.90-1.31). Post hoc analyses showed that years of education might have a possible confounding and mediating role in the association between television watching with breast and colorectal cancer. Consistent results were observed for each cancer site according to sex (colorectal cancer), anatomical subsites and cancer subtypes. There was little evidence of associations between genetically predicted computer use and cancer risk.Our univariable analysis identified some positive associations between hours of television watching and risks of breast and colorectal cancer. However, further adjustment for additional lifestyle factors especially years of education attenuated these results. Future studies using objective measures of exposure can provide new insights into the possible role of sedentary behaviour in cancer development.
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000286611 650_7 $$2Other$$aMendelian randomisation
000286611 650_7 $$2Other$$abreast cancer
000286611 650_7 $$2Other$$acolorectal cancer
000286611 650_7 $$2Other$$aprostate cancer
000286611 650_7 $$2Other$$asedentary activities
000286611 7001_ $$aKazmi, Nabila$$b1
000286611 7001_ $$aDimou, Niki$$b2
000286611 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b3
000286611 7001_ $$aMartin, Richard M$$b4
000286611 7001_ $$aLewis, Sarah J$$b5
000286611 7001_ $$aLynch, Brigid M$$b6
000286611 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b7$$udkfz
000286611 7001_ $$aKweon, Sun-Seog$$b8
000286611 7001_ $$aLi, Li$$b9
000286611 7001_ $$aMilne, Roger L$$b10
000286611 7001_ $$aSakoda, Lori C$$b11
000286611 7001_ $$aSchoen, Robert E$$b12
000286611 7001_ $$aPhipps, Amanda I$$b13
000286611 7001_ $$aFigueiredo, Jane C$$b14
000286611 7001_ $$aPeters, Ulrike$$b15
000286611 7001_ $$aDixon-Suen, Suzanne C$$b16
000286611 7001_ $$aGunter, Marc J$$b17
000286611 7001_ $$aMurphy, Neil$$b18
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