TY  - JOUR
AU  - Papadimitriou, Nikos
AU  - Kazmi, Nabila
AU  - Dimou, Niki
AU  - Tsilidis, Konstantinos K
AU  - Martin, Richard M
AU  - Lewis, Sarah J
AU  - Lynch, Brigid M
AU  - Hoffmeister, Michael
AU  - Kweon, Sun-Seog
AU  - Li, Li
AU  - Milne, Roger L
AU  - Sakoda, Lori C
AU  - Schoen, Robert E
AU  - Phipps, Amanda I
AU  - Figueiredo, Jane C
AU  - Peters, Ulrike
AU  - Dixon-Suen, Suzanne C
AU  - Gunter, Marc J
AU  - Murphy, Neil
TI  - Leisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis.
JO  - Cancer medicine
VL  - 13
IS  - 1
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2023-02823
SP  - e6732
PY  - 2024
N1  - 2024 Jan;13(1):e6732
AB  - Sedentary behaviours have been associated with increased risks of some common cancers in epidemiological studies; however, it is unclear if these associations are causal.We used univariable and multivariable two-sample Mendelian randomisation (MR) to examine potential causal relationships between sedentary behaviours and risks of breast, colorectal and prostate cancer. Genetic variants associated with self-reported leisure television watching and computer use were identified from a recent genome-wide association study (GWAS). Data related to cancer risk were obtained from cancer GWAS consortia. A series of sensitivity analyses were applied to examine the robustness of the results to the presence of confounding.A 1-standard deviation (SD: 1.5 h/day) increment in hours of television watching increased risk of breast cancer (OR per 1-SD: 1.15, 95
KW  - Mendelian randomisation (Other)
KW  - breast cancer (Other)
KW  - colorectal cancer (Other)
KW  - prostate cancer (Other)
KW  - sedentary activities (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38155458
DO  - DOI:10.1002/cam4.6732
UR  - https://inrepo02.dkfz.de/record/286611
ER  -