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@ARTICLE{Papadimitriou:286611,
      author       = {N. Papadimitriou and N. Kazmi and N. Dimou and K. K.
                      Tsilidis and R. M. Martin and S. J. Lewis and B. M. Lynch
                      and M. Hoffmeister$^*$ and S.-S. Kweon and L. Li and R. L.
                      Milne and L. C. Sakoda and R. E. Schoen and A. I. Phipps and
                      J. C. Figueiredo and U. Peters and S. C. Dixon-Suen and M.
                      J. Gunter and N. Murphy},
      title        = {{L}eisure time television watching, computer use and risks
                      of breast, colorectal and prostate cancer: {A} {M}endelian
                      randomisation analysis.},
      journal      = {Cancer medicine},
      volume       = {13},
      number       = {1},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-02823},
      pages        = {e6732},
      year         = {2024},
      note         = {2024 Jan;13(1):e6732},
      abstract     = {Sedentary behaviours have been associated with increased
                      risks of some common cancers in epidemiological studies;
                      however, it is unclear if these associations are causal.We
                      used univariable and multivariable two-sample Mendelian
                      randomisation (MR) to examine potential causal relationships
                      between sedentary behaviours and risks of breast, colorectal
                      and prostate cancer. Genetic variants associated with
                      self-reported leisure television watching and computer use
                      were identified from a recent genome-wide association study
                      (GWAS). Data related to cancer risk were obtained from
                      cancer GWAS consortia. A series of sensitivity analyses were
                      applied to examine the robustness of the results to the
                      presence of confounding.A 1-standard deviation (SD: 1.5
                      h/day) increment in hours of television watching increased
                      risk of breast cancer (OR per 1-SD: 1.15, $95\%$ confidence
                      interval [CI]: 1.05-1.26) and colorectal cancer (OR per
                      1-SD: 1.32, $95\%$ CI: 1.16-1.49) while there was little
                      evidence of an association for prostate cancer risk (OR per
                      1-SD: 0.94, $95\%$ CI: 0.84-1.06). After adjusting for years
                      of education, the effect estimates for television watching
                      were attenuated (breast cancer, OR per 1-SD: 1.08, $95\%$
                      CI: 0.92-1.27; colorectal cancer, OR per 1-SD: 1.08, $95\%$
                      CI: 0.90-1.31). Post hoc analyses showed that years of
                      education might have a possible confounding and mediating
                      role in the association between television watching with
                      breast and colorectal cancer. Consistent results were
                      observed for each cancer site according to sex (colorectal
                      cancer), anatomical subsites and cancer subtypes. There was
                      little evidence of associations between genetically
                      predicted computer use and cancer risk.Our univariable
                      analysis identified some positive associations between hours
                      of television watching and risks of breast and colorectal
                      cancer. However, further adjustment for additional lifestyle
                      factors especially years of education attenuated these
                      results. Future studies using objective measures of exposure
                      can provide new insights into the possible role of sedentary
                      behaviour in cancer development.},
      keywords     = {Mendelian randomisation (Other) / breast cancer (Other) /
                      colorectal cancer (Other) / prostate cancer (Other) /
                      sedentary activities (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38155458},
      doi          = {10.1002/cam4.6732},
      url          = {https://inrepo02.dkfz.de/record/286611},
}