000286615 001__ 286615
000286615 005__ 20240506154129.0
000286615 0247_ $$2doi$$a10.1111/pcmr.13155
000286615 0247_ $$2pmid$$apmid:38153178
000286615 0247_ $$2ISSN$$a1755-1471
000286615 0247_ $$2ISSN$$a0893-5785
000286615 0247_ $$2ISSN$$a1600-0749
000286615 0247_ $$2ISSN$$a1755-148X
000286615 0247_ $$2altmetric$$aaltmetric:157881574
000286615 037__ $$aDKFZ-2023-02827
000286615 041__ $$aEnglish
000286615 082__ $$a610
000286615 1001_ $$00000-0003-2972-7222$$aManrique-Silva, Esperanza$$b0
000286615 245__ $$aClinical, histological, and molecular differences in melanoma due to different TERT promoter mutations subtypes. A retrospective cross-sectional study in 684 melanoma patients.
000286615 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2024
000286615 3367_ $$2DRIVER$$aarticle
000286615 3367_ $$2DataCite$$aOutput Types/Journal article
000286615 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1715002842_13242
000286615 3367_ $$2BibTeX$$aARTICLE
000286615 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000286615 3367_ $$00$$2EndNote$$aJournal Article
000286615 500__ $$a2024 May;37(3):343-351
000286615 520__ $$aDifferences in survival according to the pTERT mutation subtypes (-124C > T, -146C > T, and tandem -138_139CC > TT) have been observed. The present study aimed to describe the clinical as the histopathological and molecular cutaneous melanoma features according to the presence of the three most prevalent pTERT mutation subtypes (-124C > T, -146C > T, and tandem -138_139CC > TT). A retrospective cross-sectional study including 684 patients was designed, and a Partial Least-Squares Discriminant Analysis (PLS-DA) was performed. After the PSL-DA, it was observed that the tandem -138_139CC > TT subtype differs from the other subtypes. The model demonstrated that the -124C > T and the -138_139 CC > TT subtypes were associated with fast-growing melanomas (OR 0.5, CI 0.29-0.86, p = .012) and with Breslow >2 mm (OR 0.6, CI 0.37-0.97, p = .037), compared to the -146C > T mutation. Finally, the -124C > T appeared to be more associated with the presence of TILs (non-brisk) than the -146C > T (OR 0.6, CI 0.40-1.01, p = .05). These findings confirmed that the -124C > T and the tandem -138_139 CC > TT subtypes are both highly associated with the presence of features of aggressiveness; however, only the -124C > T was highly associated with TILs. This difference could explain the worse survival rate associated with the tandem -138_139CC > TT mutations.
000286615 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000286615 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000286615 650_7 $$2Other$$abiomarkers
000286615 650_7 $$2Other$$agenetics
000286615 650_7 $$2Other$$amelanoma
000286615 650_7 $$2Other$$aoncology
000286615 650_7 $$2Other$$atranslational research
000286615 7001_ $$aDavid, Millán-Esteban$$b1
000286615 7001_ $$aMaider, Aguerralde-Martin$$b2
000286615 7001_ $$aGarcía-Casado, Zaida$$b3
000286615 7001_ $$aMoro, Ruggero$$b4
000286615 7001_ $$aRequena, Celia$$b5
000286615 7001_ $$aTravés, Victor$$b6
000286615 7001_ $$aVirós, Amaya$$b7
000286615 7001_ $$0P:(DE-He78)9a9af43c15771eaf3b2db8bb28a2829d$$aKumar, Rajiv$$b8
000286615 7001_ $$00000-0003-3433-8707$$aNagore, Eduardo$$b9
000286615 773__ $$0PERI:(DE-600)2425880-5$$a10.1111/pcmr.13155$$gp. pcmr.13155$$n3$$p343-351$$tPigment cell & melanoma research$$v37$$x1755-1471$$y2024
000286615 909CO $$ooai:inrepo02.dkfz.de:286615$$pVDB
000286615 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9a9af43c15771eaf3b2db8bb28a2829d$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000286615 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000286615 9141_ $$y2023
000286615 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2023-10-25$$wger
000286615 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPIGM CELL MELANOMA R : 2022$$d2023-10-25
000286615 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-10-25
000286615 9201_ $$0I:(DE-He78)C050-20160331$$kC050$$lMolekular-Genetische Epidemiologie$$x0
000286615 980__ $$ajournal
000286615 980__ $$aVDB
000286615 980__ $$aI:(DE-He78)C050-20160331
000286615 980__ $$aUNRESTRICTED