% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{ManriqueSilva:286615,
      author       = {E. Manrique-Silva and M.-E. David and A.-M. Maider and Z.
                      García-Casado and R. Moro and C. Requena and V. Través and
                      A. Virós and R. Kumar$^*$ and E. Nagore},
      title        = {{C}linical, histological, and molecular differences in
                      melanoma due to different {TERT} promoter mutations
                      subtypes. {A} retrospective cross-sectional study in 684
                      melanoma patients.},
      journal      = {Pigment cell $\&$ melanoma research},
      volume       = {37},
      number       = {3},
      issn         = {1755-1471},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2023-02827},
      pages        = {343-351},
      year         = {2024},
      note         = {2024 May;37(3):343-351},
      abstract     = {Differences in survival according to the pTERT mutation
                      subtypes (-124C > T, -146C > T, and tandem $-138_139CC$ >
                      TT) have been observed. The present study aimed to describe
                      the clinical as the histopathological and molecular
                      cutaneous melanoma features according to the presence of the
                      three most prevalent pTERT mutation subtypes (-124C > T,
                      -146C > T, and tandem $-138_139CC$ > TT). A retrospective
                      cross-sectional study including 684 patients was designed,
                      and a Partial Least-Squares Discriminant Analysis (PLS-DA)
                      was performed. After the PSL-DA, it was observed that the
                      tandem $-138_139CC$ > TT subtype differs from the other
                      subtypes. The model demonstrated that the -124C > T and the
                      $-138_139$ CC > TT subtypes were associated with
                      fast-growing melanomas (OR 0.5, CI 0.29-0.86, p = .012) and
                      with Breslow >2 mm (OR 0.6, CI 0.37-0.97, p = .037),
                      compared to the -146C > T mutation. Finally, the -124C > T
                      appeared to be more associated with the presence of TILs
                      (non-brisk) than the -146C > T (OR 0.6, CI 0.40-1.01, p =
                      .05). These findings confirmed that the -124C > T and the
                      tandem $-138_139$ CC > TT subtypes are both highly
                      associated with the presence of features of aggressiveness;
                      however, only the -124C > T was highly associated with TILs.
                      This difference could explain the worse survival rate
                      associated with the tandem $-138_139CC$ > TT mutations.},
      keywords     = {biomarkers (Other) / genetics (Other) / melanoma (Other) /
                      oncology (Other) / translational research (Other)},
      cin          = {C050},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38153178},
      doi          = {10.1111/pcmr.13155},
      url          = {https://inrepo02.dkfz.de/record/286615},
}