%0 Journal Article
%A Tenbergen, Carlijn J A
%A Fortuin, Ansje S
%A van Asten, Jack J A
%A Veltien, Andor
%A Philips, Bart W J
%A Hambrock, Thomas
%A Orzada, Stephan
%A Quick, Harald H
%A Barentsz, Jelle O
%A Maas, Marnix C
%A Scheenen, Tom W J
%T The Potential of Iron Oxide Nanoparticle-Enhanced MRI at 7 T Compared With 3 T for Detecting Small Suspicious Lymph Nodes in Patients With Prostate Cancer.
%J Investigative radiology
%V 59
%N 7
%@ 0020-9996
%C [Erscheinungsort nicht ermittelbar]
%I Ovid
%M DKFZ-2024-00015
%P 519-525
%D 2024
%Z 2024 Jul 1;59(7):519-525
%X Accurate detection of lymph node (LN) metastases in prostate cancer (PCa) is a challenging but crucial step for disease staging. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) enables distinction between healthy LNs and nodes suspicious for harboring metastases. When combined with MRI at an ultra-high magnetic field, an unprecedented spatial resolution can be exploited to visualize these LNs.The aim of this study was to explore USPIO-enhanced MRI at 7 T in comparison to 3 T for the detection of small suspicious LNs in the same cohort of patients with PCa.Twenty PCa patients with high-risk primary or recurrent disease were referred to our hospital for an investigational USPIO-enhanced 3 T MRI examination with ferumoxtran-10. With consent, they underwent a 7 T MRI on the same day. Three-dimensional anatomical and T2*-weighted images of both examinations were evaluated blinded, with an interval, by 2 readers who annotated LNs suspicious for metastases. Number, size, and level of suspicion (LoS) of LNs were paired within patients and compared between field strengths.At 7 T, both readers annotated significantly more LNs compared with 3 T (474 and 284 vs 344 and 162), with 116 suspicious LNs on 7 T (range, 1-34 per patient) and 79 suspicious LNs on 3 T (range, 1-14 per patient) in 17 patients. For suspicious LNs, the median short axis diameter was 2.6 mm on 7 T (1.3-9.5 mm) and 2.8 mm for 3 T (1.7-10.4 mm, P = 0.05), with large overlap in short axis of annotated LNs between LoS groups. At 7 T, significantly more suspicious LNs had a short axis <2.5 mm compared with 3 T (44
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38157433
%R 10.1097/RLI.0000000000001056
%U https://inrepo02.dkfz.de/record/286647