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@ARTICLE{Tenbergen:286647,
      author       = {C. J. A. Tenbergen and A. S. Fortuin and J. J. A. van Asten
                      and A. Veltien and B. W. J. Philips and T. Hambrock and S.
                      Orzada$^*$ and H. H. Quick and J. O. Barentsz and M. C. Maas
                      and T. W. J. Scheenen},
      title        = {{T}he {P}otential of {I}ron {O}xide
                      {N}anoparticle-{E}nhanced {MRI} at 7 {T} {C}ompared {W}ith 3
                      {T} for {D}etecting {S}mall {S}uspicious {L}ymph {N}odes in
                      {P}atients {W}ith {P}rostate {C}ancer.},
      journal      = {Investigative radiology},
      volume       = {59},
      number       = {7},
      issn         = {0020-9996},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2024-00015},
      pages        = {519-525},
      year         = {2024},
      note         = {2024 Jul 1;59(7):519-525},
      abstract     = {Accurate detection of lymph node (LN) metastases in
                      prostate cancer (PCa) is a challenging but crucial step for
                      disease staging. Ultrasmall superparamagnetic iron oxide
                      (USPIO)-enhanced magnetic resonance imaging (MRI) enables
                      distinction between healthy LNs and nodes suspicious for
                      harboring metastases. When combined with MRI at an
                      ultra-high magnetic field, an unprecedented spatial
                      resolution can be exploited to visualize these LNs.The aim
                      of this study was to explore USPIO-enhanced MRI at 7 T in
                      comparison to 3 T for the detection of small suspicious LNs
                      in the same cohort of patients with PCa.Twenty PCa patients
                      with high-risk primary or recurrent disease were referred to
                      our hospital for an investigational USPIO-enhanced 3 T MRI
                      examination with ferumoxtran-10. With consent, they
                      underwent a 7 T MRI on the same day. Three-dimensional
                      anatomical and T2*-weighted images of both examinations were
                      evaluated blinded, with an interval, by 2 readers who
                      annotated LNs suspicious for metastases. Number, size, and
                      level of suspicion (LoS) of LNs were paired within patients
                      and compared between field strengths.At 7 T, both readers
                      annotated significantly more LNs compared with 3 T (474 and
                      284 vs 344 and 162), with 116 suspicious LNs on 7 T (range,
                      1-34 per patient) and 79 suspicious LNs on 3 T (range, 1-14
                      per patient) in 17 patients. For suspicious LNs, the median
                      short axis diameter was 2.6 mm on 7 T (1.3-9.5 mm) and 2.8
                      mm for 3 T (1.7-10.4 mm, P = 0.05), with large overlap in
                      short axis of annotated LNs between LoS groups. At 7 T,
                      significantly more suspicious LNs had a short axis <2.5 mm
                      compared with 3 T $(44\%$ vs $27\%).$ Magnetic resonance
                      imaging at 7 T provided better image quality and structure
                      delineation and a higher LoS score for suspicious nodes.In
                      the same cohort of patients with PCa, more and more small
                      LNs were detected on 7 T USPIO-enhanced MRI compared with 3
                      T MRI. Suspicious LNs are generally very small, and
                      increased nodal size was not a good indication of suspicion
                      for the presence of metastases. The high spatial resolution
                      of USPIO-enhanced MRI at 7 T improves structure delineation
                      and the visibility of very small suspicious LNs, potentially
                      expanding the in vivo detection limits of pelvic LN
                      metastases in PCa patients.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38157433},
      doi          = {10.1097/RLI.0000000000001056},
      url          = {https://inrepo02.dkfz.de/record/286647},
}