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| Home > Publications database > The Potential of Iron Oxide Nanoparticle-Enhanced MRI at 7 T Compared With 3 T for Detecting Small Suspicious Lymph Nodes in Patients With Prostate Cancer. > print |
| 001 | 286647 | ||
| 005 | 20240610104626.0 | ||
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| 100 | 1 | _ | |a Tenbergen, Carlijn J A |b 0 |
| 245 | _ | _ | |a The Potential of Iron Oxide Nanoparticle-Enhanced MRI at 7 T Compared With 3 T for Detecting Small Suspicious Lymph Nodes in Patients With Prostate Cancer. |
| 260 | _ | _ | |a [Erscheinungsort nicht ermittelbar] |c 2024 |b Ovid |
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| 500 | _ | _ | |a 2024 Jul 1;59(7):519-525 |
| 520 | _ | _ | |a Accurate detection of lymph node (LN) metastases in prostate cancer (PCa) is a challenging but crucial step for disease staging. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) enables distinction between healthy LNs and nodes suspicious for harboring metastases. When combined with MRI at an ultra-high magnetic field, an unprecedented spatial resolution can be exploited to visualize these LNs.The aim of this study was to explore USPIO-enhanced MRI at 7 T in comparison to 3 T for the detection of small suspicious LNs in the same cohort of patients with PCa.Twenty PCa patients with high-risk primary or recurrent disease were referred to our hospital for an investigational USPIO-enhanced 3 T MRI examination with ferumoxtran-10. With consent, they underwent a 7 T MRI on the same day. Three-dimensional anatomical and T2*-weighted images of both examinations were evaluated blinded, with an interval, by 2 readers who annotated LNs suspicious for metastases. Number, size, and level of suspicion (LoS) of LNs were paired within patients and compared between field strengths.At 7 T, both readers annotated significantly more LNs compared with 3 T (474 and 284 vs 344 and 162), with 116 suspicious LNs on 7 T (range, 1-34 per patient) and 79 suspicious LNs on 3 T (range, 1-14 per patient) in 17 patients. For suspicious LNs, the median short axis diameter was 2.6 mm on 7 T (1.3-9.5 mm) and 2.8 mm for 3 T (1.7-10.4 mm, P = 0.05), with large overlap in short axis of annotated LNs between LoS groups. At 7 T, significantly more suspicious LNs had a short axis <2.5 mm compared with 3 T (44% vs 27%). Magnetic resonance imaging at 7 T provided better image quality and structure delineation and a higher LoS score for suspicious nodes.In the same cohort of patients with PCa, more and more small LNs were detected on 7 T USPIO-enhanced MRI compared with 3 T MRI. Suspicious LNs are generally very small, and increased nodal size was not a good indication of suspicion for the presence of metastases. The high spatial resolution of USPIO-enhanced MRI at 7 T improves structure delineation and the visibility of very small suspicious LNs, potentially expanding the in vivo detection limits of pelvic LN metastases in PCa patients. |
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| 700 | 1 | _ | |a Fortuin, Ansje S |b 1 |
| 700 | 1 | _ | |a van Asten, Jack J A |b 2 |
| 700 | 1 | _ | |a Veltien, Andor |b 3 |
| 700 | 1 | _ | |a Philips, Bart W J |b 4 |
| 700 | 1 | _ | |a Hambrock, Thomas |b 5 |
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| 700 | 1 | _ | |a Quick, Harald H |b 7 |
| 700 | 1 | _ | |a Barentsz, Jelle O |b 8 |
| 700 | 1 | _ | |a Maas, Marnix C |b 9 |
| 700 | 1 | _ | |a Scheenen, Tom W J |b 10 |
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