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000286713 1001_ $$aMontero-Vergara, Jetsy$$b0
000286713 245__ $$aGRB2 is a BECN1 interacting protein that regulates autophagy.
000286713 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2024
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000286713 520__ $$aGRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation of the class III PI3Kinase VPS34 activity. In ovo studies in a CAM (Chicken Chorioallantoic Membrane) model indicated that GRB2 knockdown, as well as overexpression of GRB2 loss-of-function mutants (Y52A and S86A-R88A) compromised tumor growth. These differences in tumor growth correlated with differential autophagy activity, indicating that autophagy effects might be related to the effects on tumorigenesis. Our data highlight a novel function of GRB2 as a BECN1 binding protein and a regulator of autophagy.
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000286713 7001_ $$aPlachetta, Kira$$b1
000286713 7001_ $$aKinch, Lisa$$b2
000286713 7001_ $$0P:(DE-He78)a579c50f194e70e6a847c032c0a5e73b$$aBernhardt, Stephan$$b3
000286713 7001_ $$aKashyap, Kriti$$b4
000286713 7001_ $$aLevine, Beth$$b5
000286713 7001_ $$aThukral, Lipi$$b6
000286713 7001_ $$00000-0002-6642-9585$$aVetter, Martina$$b7
000286713 7001_ $$aThomssen, Christoph$$b8
000286713 7001_ $$0P:(DE-He78)f6bebe05e7a748d3cbf9f59659567d52$$aWiemann, Stefan$$b9$$udkfz
000286713 7001_ $$0P:(DE-He78)27e110c11bce41980c004533253cdc78$$aPeña-Llopis, Samuel$$b10$$udkfz
000286713 7001_ $$00000-0003-1058-2107$$aJendrossek, Verena$$b11
000286713 7001_ $$00000-0002-4196-8996$$aVega-Rubin-de-Celis, Silvia$$b12
000286713 773__ $$0PERI:(DE-600)2541626-1$$a10.1038/s41419-023-06387-7$$gVol. 15, no. 1, p. 14$$n1$$p14$$tCell death & disease$$v15$$x2041-4889$$y2024
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