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@ARTICLE{MonteroVergara:286713,
      author       = {J. Montero-Vergara and K. Plachetta and L. Kinch and S.
                      Bernhardt$^*$ and K. Kashyap and B. Levine and L. Thukral
                      and M. Vetter and C. Thomssen and S. Wiemann$^*$ and S.
                      Peña-Llopis$^*$ and V. Jendrossek and S.
                      Vega-Rubin-de-Celis},
      title        = {{GRB}2 is a {BECN}1 interacting protein that regulates
                      autophagy.},
      journal      = {Cell death $\&$ disease},
      volume       = {15},
      number       = {1},
      issn         = {2041-4889},
      address      = {London [u.a.]},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2024-00053},
      pages        = {14},
      year         = {2024},
      abstract     = {GRB2 is an adaptor protein of HER2 (and several other
                      tyrosine kinases), which we identified as a novel BECN1
                      (Beclin 1) interacting partner. GRB2 co-immunoprecipitated
                      with BECN1 in several breast cancer cell lines and regulates
                      autophagy through a mechanism involving the modulation of
                      the class III PI3Kinase VPS34 activity. In ovo studies in a
                      CAM (Chicken Chorioallantoic Membrane) model indicated that
                      GRB2 knockdown, as well as overexpression of GRB2
                      loss-of-function mutants (Y52A and S86A-R88A) compromised
                      tumor growth. These differences in tumor growth correlated
                      with differential autophagy activity, indicating that
                      autophagy effects might be related to the effects on
                      tumorigenesis. Our data highlight a novel function of GRB2
                      as a BECN1 binding protein and a regulator of autophagy.},
      cin          = {B050 / ED01},
      ddc          = {570},
      cid          = {I:(DE-He78)B050-20160331 / I:(DE-He78)ED01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38182563},
      pmc          = {pmc:PMC10770341},
      doi          = {10.1038/s41419-023-06387-7},
      url          = {https://inrepo02.dkfz.de/record/286713},
}