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024 7 _ |a 10.1038/s41419-023-06387-7
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100 1 _ |a Montero-Vergara, Jetsy
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245 _ _ |a GRB2 is a BECN1 interacting protein that regulates autophagy.
260 _ _ |a London [u.a.]
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520 _ _ |a GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation of the class III PI3Kinase VPS34 activity. In ovo studies in a CAM (Chicken Chorioallantoic Membrane) model indicated that GRB2 knockdown, as well as overexpression of GRB2 loss-of-function mutants (Y52A and S86A-R88A) compromised tumor growth. These differences in tumor growth correlated with differential autophagy activity, indicating that autophagy effects might be related to the effects on tumorigenesis. Our data highlight a novel function of GRB2 as a BECN1 binding protein and a regulator of autophagy.
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700 1 _ |a Plachetta, Kira
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700 1 _ |a Kinch, Lisa
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700 1 _ |a Bernhardt, Stephan
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700 1 _ |a Kashyap, Kriti
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700 1 _ |a Levine, Beth
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700 1 _ |a Thukral, Lipi
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700 1 _ |a Vetter, Martina
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700 1 _ |a Thomssen, Christoph
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700 1 _ |a Wiemann, Stefan
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700 1 _ |a Peña-Llopis, Samuel
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700 1 _ |a Jendrossek, Verena
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700 1 _ |a Vega-Rubin-de-Celis, Silvia
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773 _ _ |a 10.1038/s41419-023-06387-7
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856 4 _ |u https://inrepo02.dkfz.de/record/286713/files/s41419-023-06387-7.pdf
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