% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Stepien:286717,
      author       = {N. Stepien and L. Mayr and M. T. Schmook and A. Raimann and
                      C. Dorfer and A. Peyrl and A. A. Azizi and K. Schramm$^*$
                      and C. Haberler and J. Gojo},
      title        = {{F}easibility and antitumour activity of the {FGFR}
                      inhibitor erdafitnib in three paediatric {CNS} tumour
                      patients.},
      journal      = {Pediatric blood $\&$ cancer},
      volume       = {71},
      number       = {3},
      issn         = {1545-5009},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-00057},
      pages        = {e30836},
      year         = {2024},
      note         = {2024 Mar;71(3):e30836},
      abstract     = {Alterations of the fibroblast growth factor (FGF)
                      signalling pathway are increasingly recognized as frequent
                      oncogenic drivers of paediatric brain tumours. We report on
                      three patients treated with the selective FGFR1-4 inhibitor
                      erdafitinib. Two patients were diagnosed with a posterior
                      fossa ependymoma group A (PFA EPN) and one with a low-grade
                      glioma (LGG), harbouring FGFR3/FGFR1 overexpression and an
                      FGFR1 internal tandem duplication (ITD), respectively. While
                      both EPN patients did not respond to erdafitinib treatment,
                      the FGFR1-ITD-harbouring tumour showed a significant
                      decrease in tumour volume and contrast enhancement
                      throughout treatment. The tumour remained stable 6 months
                      after treatment discontinuation.},
      keywords     = {CNS tumours (Other) / ependymoma (Other) / erdafitinib
                      (Other) / fibroblast growth factor receptor (Other) /
                      internal tandem duplication (ITD) (Other) / low-grade glioma
                      (Other) / paediatrics (Other)},
      cin          = {B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38177074},
      doi          = {10.1002/pbc.30836},
      url          = {https://inrepo02.dkfz.de/record/286717},
}